20.500.12556/RUL-177997 Coupling anisotropic curvature and nematic order mechanisms of membrane shape remodeling This study theoretically investigates how anisotropic curved membrane components (CMCs) control vesicle morphology through curvature sensing, nematic alignment, topological defects and volume constraints. By comparing arc- and saddle-shaped CMCs, we identify a rich spectrum of steady-state phases. For fully CMC-covered vesicles, arc-shaped components drive a pearling-to-cylinder transition as nematic interactions strengthen, while on partially CMC-covered vesicles the saddle-shaped CMCs stabilize necks between the convex regions of bare membrane. We map the steady-state shapes of vesicles partially covered by arc- and saddle-shaped CMCs, exposing how different vesicle shapes depend on the interplay between nematic interactions and volume constraints, revealing several novel phases. By investigating the in-plane nematic field, we find that topological defects consistently localize to high-curvature regions, revealing how intrinsic and deviatoric curvature effects cooperate in membrane remodeling. These findings establish a unified framework for understanding how proteins and lipid domains with anisotropic intrinsic curvature shape cellular structures—from organelle morphogenesis to global cell shape. lipid bilayer simulations Monte-Carlo curvature cells lipidni dvosloj simulacije Monte-Carlo ukrivljenost celice true false true Angleški jezik Slovenski jezik Članek v reviji 2026-01-15 14:53:23 2026-01-15 14:53:29 2026-01-16 04:22:25 0000-00-00 00:00:00 2025 0 0 Str. 8407-8428 no. 44 Vol. 21 28. November 2025 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 577 1744-6848 10.1039/D5SM00620A 248952579 https://pubs.rsc.org/en/content/articlelanding/2025/sm/d5sm00620a 1 8b48eb0d-f219-11f0-bf92-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=225478 d5sm00620a_(1).pdf d5sm00620a_(1).pdf 1 AD21C790463328FEFD97D8580785D3F3 15bafc4b3e3e0980df425a40f36319c83ad3184c661f085d9f44b539168d707d 25fc7c2f-f21a-11f0-bf92-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=225479 Fakulteta za elektrotehniko Zdravstvena fakulteta 0 0 0