20.500.12556/RUL-177935 Defining bath ankylosing spondylitis disease activity index cut-off values for disease activity states in a multinational european cohort of patients with axial spondyloarthritis Objective: The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) is widely used for assessing disease activity in patients with axial spondyloarthritis (axSpA), particularly in settings where markers of inflammation are unavailable. As no consensus on BASDAI cut-off values exists for disease activity states in axSpA, we aimed to develop and validate such cut-offs against external criteria. Methods: Routine care patients with axSpA initiating a biologic disease-modifying antirheumatic drug in eight European registries were included. Receiver operating characteristic analyses against external criteria were performed to determine optimal BASDAI values for separating remission, low disease activity (LDA), high disease activity (HDA), and very high disease activity (VHDA). Follow-up data at 6 months were used to select BASDAI cut-off values between remission and LDA and between LDA and HDA, whereas baseline data were used to select the cut-off for VHDA. The level of agreement between disease activity states based on BASDAI and Axial Spondyloarthritis Disease Activity Score (ASDAS) cut-off values was assessed using the proportion of discordance and weighted kappa. Results: In this cohort of 4,633 patients, the optimal BASDAI cut-off values between remission, LDA, HDA and VHDA were estimated to be <1.3, <2.5, and >5.3. The proportions of discordance between BASDAI and ASDAS disease activity states were 27.6% (weighted κ = 0.48) in baseline data and 37.6% (weighted κ = 0.28) in 6-month data. Conclusion: BASDAI cut-off values for separating remission, LDA, HDA and VHDA were estimated in >4,600 patients. These cut-off values can be used for assessing disease activity and monitoring patients with axSpA, particularly when laboratory markers are unavailable. disease activity states ankylosing spondylitis axial spondyloarthritis multinational European cohort stanja aktivnosti bolezni a nkilozirajoči spondilitis aksialni spondiloartritis multinacionalna evropska kohorta true false true Angleški jezik Slovenski jezik Članek v reviji 2026-01-14 04:34:03 2026-01-15 10:14:01 2026-07-23 11:51:44 0000-00-00 00:00:00 2025 0 0 11 str. iss. 12, art. e70125 Vol. 7 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-002 2578-5745 10.1002/acr2.70125 261989635 RAZ_Georgiadis_Stylianos_2025.pdf RAZ_Georgiadis_Stylianos_2025.pdf 1 D03FB1BFBFBE0FDADCF305C6F07498B0 c677dbf3a139b3086cbb1e7f3ccf897eaee6384e0ab6cef99500fcc05d9fdcf0 c912edff-f1f2-11f0-bf92-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=225472 https://pmc.ncbi.nlm.nih.gov/articles/PMC12670041/pdf/ACR2-7-e70125.pdf 1 dbb49cfc-f0f9-11f0-bf92-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=225379 Medicinska fakulteta 0 0 0