20.500.12556/RUL-177805 Circular RNA in hepatocellular carcinoma emerging therapeutic strategies Circular RNAs, or circRNAs, are unique single-stranded RNA molecules that form covalently closed circles. They possess a wide range of cellular functions and can act as tumor suppressors or promoters, regulating various aspects of carcinogenesis. These functions include acting as microRNA sponges, nteracting with and binding to proteins and mRNA, regulating transcription and RNA splicing, translating into proteins, and serving as cargo in exosomes. Due to their diverse cellular roles and enhanced molecular stability, circRNAs are not only promising biomarkers but also emerging candidates for the development of RNA-based therapeutics. In this review, we explored the therapeutic potential of circular RNA by reviewing the current state of the art n the field of oncology, with a particular focus on hepatocellular carcinoma. Based on their endogenous functions, circular RNA can be designed, synthesized and delivered to produce various proteins, such as neoantigens and cytokines, or to sequester oncogenic microRNA in tumor cells. Although many therapeutic applications of circular RNA are still in the early stages of development, they have already shown promising results in both in vitro and in vivo animal models. In summary, circular RNAs are emerging as both therapeutics and biomarkers in iver cancer and broader oncology, with relevant clinical applicability, particularly n immunotherapy. RNA-based therapeutics circRNA circRNA-based therapeutics hepatocellular carcinoma immunotherapy terapija na osnovi RNA cirkularna RNA terapija na osnovi cirkularne RNA hepatocelularni karcinom imunoterapija true false true Angleški jezik Slovenski jezik Članek v reviji 2026-01-08 07:51:49 2026-01-08 07:51:55 2026-01-20 12:26:16 0000-00-00 00:00:00 2025 0 0 16 str. art. 1722576 Vol. 16 Dec. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2025-11-20 2025-11-25 2025-12-09 577.2 1664-3224 10.3389/fimmu.2025.1722576 263803139 Jazbec_Gregor.pdf Jazbec_Gregor.pdf 1 C1AD91F38CCF8CED361B2626B024B656 fd2bfb87220042df854fce601e37b6923404a5a8b2b2b406f5cbd5d9439a3e7c faba5a90-ec60-11f0-bf92-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=225134 https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1722576/full 1 84aceadb-ec5e-11f0-bf92-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=225133 Medicinska fakulteta 0 0 0