20.500.12556/RUL-177541 Impact of incretin-based therapy on skeletal muscle health Skeletal muscle is the largest insulin-sensitive tissue in the human body, playing a crucial role in glucose homeostasis, body mobility and overall metabolic health. In obesity and type 2 diabetes (T2D), skeletal muscle undergoes structural, functional, and metabolic alterations, including reduced muscle mass, impaired contractile function, increased myosteatosis, mitochondrial dysfunction, and chronic low-grade inflammation. Incretin-based therapies such as glucagon-like peptide-1 receptor agonists (GLP-1 RAs) or dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) RAs are highly effective treatments for T2D and obesity, producing substantial weight loss. While clinical trials suggest proportional loss of fat and lean mass when using incretin-based therapies, emerging preclinical and translational data indicate potential muscle-specific beneficial effects such as attenuation of atrophy, improved myogenesis, enhanced mitochondrial function and reduced myosteatosis. This review comprehensively summarizes the current preclinical and clinical evidence on the impact of incretin-based therapies on skeletal muscle mass, composition, metabolism, and performance, focusing on mechanistic insights from animal models and translational findings from human studies. obesity incretin-based treatment liraglutide debelost zdravljenje na osnovi inkretinov liraglutid true false true Angleški jezik Slovenski jezik Članek v reviji 2025-12-24 04:39:26 2025-12-24 11:03:52 2026-07-31 14:06:22 0000-00-00 00:00:00 2025 0 0 16 str. iss. 9, art. 1691 Vol. 61 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.4 1648-9144 10.3390/medicina61091691 249529603 RAZ_Koceva_Andrijana_2025.pdf RAZ_Koceva_Andrijana_2025.pdf 1 4303C43AAF6E430AF66447FE9943A173 0ec87ff175bcd20158b2133319bf1588b1b1ee88e71820e9c9a60bd2fa07306a 2918c80d-e0af-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=224669 https://www.mdpi.com/1648-9144/61/9/1691 1 b331ac27-e079-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=224610 Medicinska fakulteta 0 0 0