20.500.12556/RUL-176658 Economic burden of heart failure in Europe a systematic review of costs and cost-effectiveness Heart failure (HF) affects over 64 million individuals worldwide and is a major cause of hospitalization and mortality, particularly among older adults. In Europe, HF imposes a significant and growing economic burden. This systematic review aimed to evaluate the economic impact of HF diagnosis, treatment and management across European healthcare systems. A systematic literature search was conducted using PubMed, Cochrane Library and Econlit databases including the terms ‘heart failure’ AND ‘costs’ OR ‘cost of illness’ OR ‘cost analysis’ OR ‘economic burden’ OR ‘cost effectiveness’ OR ‘primary care’ OR ‘secondary care’. Studies published between January 2000 and January 2024 were included. A total of 49 studies were included: 17 on resource use, 11 on costs, 15 on resource use and costs, 1 on costs and cost-effectiveness, and 5 on resource use, costs and cost-effectiveness. Hospitalizations and medication use were the most frequently reported resource parameters. Annual HF-related costs varied widely across countries, ranging from €613 to €22,647 per patient. Hospitalizations represented the primary cost driver, accounting for 15% to 92% of total HF costs. Cost-reduction strategies included multidisciplinary care, telemonitoring and pharmacologic interventions. Several disease management programmes reduced hospital admissions and emergency visits. Cost-effectiveness analyses supported the use of certain HF therapies, with incremental cost-effectiveness ratios ranging from €1490 to €9406 per QALY gained. F imposes a substantial economic burden in Europe, largely driven by hospitalizations. Cost-effective interventions such as remote monitoring and integrated care programmes can reduce this burden. Broader adoption of these strategies may improve outcomes and optimize resource allocation across healthcare systems. heart failure healthcare costs cost effectiveness economic burden srčna odpoved stroški zdravljenja cenovna učinkovitost finančno breme true false true Angleški jezik Slovenski jezik Članek v reviji 2025-12-08 09:36:45 2025-12-08 09:36:46 2025-12-23 04:04:32 0000-00-00 00:00:00 2025 0 0 14 str. no. Vol. 2025 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 616.12-008.46:614.2:33 2055-5822 10.1002/ehf2.70017 259113731 RAZ_Darba_Josep_2025.pdf RAZ_Darba_Josep_2025.pdf 1 EC62302498FCEA8F1CF3D6435AB06D21 773996ae135392bdab63e15bffa455e5ad239b0b25fbd84535daa5c354b4b6f4 40c492b4-d412-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=223132 https://onlinelibrary.wiley.com/doi/10.1002/ehf2.70017 1 9eb6d30d-d410-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=223131 Fakulteta za računalništvo in informatiko 0 0 0