20.500.12556/RUL-176650 Proportion of confirmed Lyme neuroborreliosis cases among adult patients with suspected early European Lyme neuroborreliosis Purpose To determine the frequency of confirmed Lyme neuroborreliosis (LNB) cases in adult patients with three different clinical presentations consistent with early LNB. Methods Data were obtained through routine health care at the UMC Ljubljana, Slovenia from 2005 to 2022, using clinical pathways. The patients were classified into three groups: (i) radicular pain of new onset (N=332); or (ii) involvement of cranial nerve(s) but without radicular pain (N=997); or (iii) erythema migrans (EM) skin lesion(s) in conjunction with symptoms suggestive of nervous system involvement but without either cranial nerve palsy or radicular pain (N=240). The diagnosis of LNB considered the following variables: the presence of: (1) neurologic symptoms consistent with LNB (with no other obvious explanation); (2) cerebrospinal fluid (CSF) pleocytosis (>5×10$^ 6$ leukocytes/L); and (3) demonstration of intrathecal synthesis of borrelial antibodies, and/or cultivation of borrelia from CSF, and/or the presence of EM. Patients fulfilling only the first two criteria were interpreted as having possible LNB, while those who satisfied all three criteria were regarded as having confirmed LNB. Results Of 1569 adult patients, 348 (22.2%) had confirmed LNB and 70 (4.5%) others had possible LNB. The proportion of confirmed LNB cases was the highest for patients with radicular pain (217/332, 65.4%), followed by the group with EM and neurologic symptoms (47/240, 19.6%), and those with cranial neuritis (84/997, 8.4%). Conclusion Only 22% of patients evaluated had confirmed LNB. The proportion of confirmed LNB cases correlated with clinical presentation and was highest among patients with recent onset of radicular pain. lyme borreliosis lyme neuroborreliosis criteria cerebrospinal fluid Bannwarth syndrome cranial neuritis borrelial meningitis intrathecal borrelial antibody synthesis borrelia culture true false true Angleški jezik Ni določen Članek v reviji 2025-12-07 05:36:41 2025-12-11 11:24:25 2026-05-20 11:25:13 0000-00-00 00:00:00 2025 0 0 Str. 1403–1412 iss. 4 Vol. 53 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.9 0300-8126 10.1007/s15010-024-02461-0 237288707 RAZ_Strle_Klemen_2025.pdf RAZ_Strle_Klemen_2025.pdf 1 6C9DD52CB4470B576F1B75E63D1EF7B3 5d4344b471a2932359eb9ca5ce97788f522417a35ad5da16775b685f1aa492ac 9df5ba6d-d67d-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=223417 https://link.springer.com/article/10.1007/s15010-024-02461-0 1 edde23bc-d325-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=223122 Medicinska fakulteta 0 0 0