20.500.12556/RUL-176014 Utility of hypoxic modalities for musculoskeletal injury rehabilitation in athletes a narrative review of mechanisms and contemporary perspectives Recent evidence suggests that different hypoxic modalities might accelerate the rehabilitation process in injured athletes. In this review, the application of hypoxia during rehabilitation from musculoskeletal injury is explored in relation to two principles: (1) facilitating the healing of damaged tissue, and (2) mitigating detraining and inducing training adaptations with a reduced training load. Key literature that explores the underlying mechanisms for these themes is presented, and considerations for practice and future research directions are outlined. For principle (1), passive intermittent hypoxic exposures might accelerate tissue healing through angiogenic and osteogenic mechanisms. Experimental evidence is largely derived from rodent research, so further work is warranted to establish whether clinically meaningful effects can be observed in humans, before optimal protocols are determined (duration, frequency, and hypoxic severity). Regarding principle (2), a hypoxia-related increase in the cardiometabolic stimulus imposed by low-load exercise is appealing for load-compromised athletes. As rehabilitation progresses, a variety of hypoxic modalities can be implemented to enhance adaptation to energy-systems and resistance-based training, and more efficiently return the athlete to competition readiness. While hypoxic modalities seem promising for accelerating musculoskeletal injury rehabilitation in humans, and are already being widely used in practice, a significant gap remains regarding their evidence-based application. sport detraining healing hypoxia training adaptation šport razbremenitev detrening zdravljenje hipoksija prilagoditev treninga true false true Angleški jezik Slovenski jezik Članek v reviji 2025-11-18 10:33:04 2025-11-18 10:33:06 2025-12-16 04:10:23 0000-00-00 00:00:00 2025 0 0 Str. 2227–2240 no. 19 Vol. 43 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 796.01:616.12-008.44 1466-447X 10.1080/02640414.2024.2416779 213043971 Utility_of_hypoxic_modalities_for_musculoskeletal_injury_rehabilitation_in_athletes__A_narrative_review_of_mechanisms_and_contemporary_perspectives.pdf Utility_of_hypoxic_modalities_for_musculoskeletal_injury_rehabilitation_in_athletes__A_narrative_review_of_mechanisms_and_contemporary_perspectives.pdf 1 03A7C22B57BA39A0FC613B4B20747D38 58ebf8dd538009bb2a0d8f6fadc25267343241889c78cfb748cadf3f39a3e963 8b28a988-c461-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=222048 https://www.tandfonline.com/doi/full/10.1080/02640414.2024.2416779 0 6f18fd9a-c461-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=222047 Fakulteta za šport 0 0 0