20.500.12556/RUL-175995 PLA2G4E in health and disease insights from omics and functional analyses The phospholipase A2 (PLA2) enzyme superfamily has been extensively studied, but omprehensive reviews on cytosolic phospholipase A2 group IVE (PLA2G4E) remain scarce, limiting our understanding of its role in lipid metabolism and disease. Our review synthesizes current findings on the human PLA2G4E gene and its murine ortholog Pla2g4e, drawing from multi-omics analyses and a range of functional studies. Pla2g4e exhibits distinct expression patterns across tissues, suggesting potential tissue-specific roles. In addition to its phospholipase activity, PLA2G4E exhibits N-acyltransferase activity and responds to calcium influx. Emerging evidence suggests possible involvement in metabolic disorders such as obesity and diabetes, particularly through effects on glucose uptake and insulin sensitivity. PLA2G4E has been implicated in the synthesis of N-acylethanolamines with potential effects on energy homeostasis, stress adaptation, neuronal signaling, pain perception, cognition, and motor coordination. Genomic and preliminary functional evidence further point to possible roles in immune regulation and neurobiology, with some associations reported in neurodegenerative diseases such as Alzheimer’s disease. Comprehensive insights into the biological roles of PLA2G4E are essential for clarifying its enzymatic functions and potential involvement in disease mechanisms; however, further experimental and clinical studies are needed to substantiate these emerging associations and assess its therapeutic potential. phospholipases lipid metabolism muscles adipose tissue fatty acid metabolism obesity diabetes N-acylethanolamine genetika geni PLA2G4E debelost diabetes biokemija true false true Angleški jezik Slovenski jezik Članek v reviji 2025-11-17 15:20:57 2025-11-17 15:20:58 2026-01-06 09:01:59 0000-00-00 00:00:00 2025 0 0 20 str. [article no.] ǂ101359 Vol. 100 Nov. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2025-11-01 575 1873-2194 10.1016/j.plipres.2025.101359 257136131 RAZ_Cater_Masa_2025.pdf RAZ_Cater_Masa_2025.pdf 1 98A6F92B608D680B3083C1BC71A5C092 732e0941e7ac402a16f3e299aa7f820a875f5bb50278468a665e52b32591e181 130f019f-d992-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=223701 https://www.sciencedirect.com/science/article/pii/S0163782725000414 0 f48332b4-ead5-11f0-bf92-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=225020 Biotehniška fakulteta 0 0 0