20.500.12556/RUL-175821 Deuteration of six-membered N-heteroarenes chemistry and applications Six-membered N-heteroarenes (“6NHetAr”) play pivotal roles in the pharmaceutical, agrochemical, and materials science industries. In recent times, deuterium (D)-labelled 6NHetAr have demonstrated enhanced performance over their unlabelled counterparts. For example, VV116 and VX-984, approved therapeutics for the treatment of COVID-19 and cancer, and deuterated functional materials for use as ligands in catalysts and organometallic light-emitters. As interest in this field continues to grow, there is a corresponding need to develop more efficient, scalable, and sustainable approaches to deuterate 6NHetAr. In this work, we comprehensively review approaches developed for the incorporation of D into 6NHetAr, their fused counterparts, and complex compounds containing 6NHetAr. We also provide an overview of established and emerging applications for these materials. deuteration deuterium deuterium-labelling isotope-labelling N-heteroarene N-heteroaromatic compounds pyridine pyrimidine pyrazine pyridazine quinoline quinazoline electron deficiency triazine tetrazine organic electronics pharmaceuticals dyes heteroaromatics regioselectivity deuteriranje devterij označevanje z devterijem označevanje z izotopi N-heteroaren N-heteroaromatske spojine piridin pirimidin pirazin piridazin kinolin kinazolin pomanjkanje elektronov triazin tetrazin organska elektronika farmacevtski izdelki barvila true false true Angleški jezik Slovenski jezik Članek v reviji 2025-11-10 10:18:50 2025-11-10 10:18:51 2025-12-19 04:44:46 0000-00-00 00:00:00 2025 0 0 55 str. iss. 67, art. e02659 Vol. 31 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 547.8:546.11.027*2 0947-6539 10.1002/chem.202502659 255671299 Chemistry_A_European_J_-_2025_-_Raju_-_Deuteration_of_Six‐Membered_N‐Heteroarenes__Chemistry_and_Applications.pdf Chemistry_A_European_J_-_2025_-_Raju_-_Deuteration_of_Six‐Membered_N‐Heteroarenes__Chemistry_and_Applications.pdf 1 CECC112DD6F400A3D39793075AAFB53F d0c6e142383bcb56e1338f019c45bfe38239bc51a5ce97e87dd458aa0548ec38 3be4f22f-dc18-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=224168 https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202502659 1 f1e8f5d1-be15-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=221702 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0