20.500.12556/RUL-175770 Impact of peroxide content in excipients and antioxidants on famotidine oxidative stability Famotidine, a widely used H$_2$-receptor antagonist, exhibits sensitivity to oxidative degradation, particularly in the presence of excipients containing peroxide impurities. This study explores the oxidative stability of famotidine under various storage conditions, with a specific focus on excipients with varying peroxide contents. A stability-indicating liquid chromatography-mass spectrometry (LC-MS) method was developed to identify and quantify famotidine degradation products, providing detailed insights into oxidative pathways. In addition, Zeneth software was employed to predict potential degradation products, and its predictive accuracy was evaluated against experimental findings. Antioxidants, including ascorbic acid, propyl gallate, and ethylenediaminetetraacetic acid (EDTA), were incorporated into compressed compatibility mixtures to assess their effects on peroxide-mediated degradation. While propyl gallate and EDTA consistently reduced peroxide levels and enhanced stability, ascorbic acid unexpectedly acted as a pro-oxidant under stress conditions, accelerating peroxide formation in povidone. These findings provide critical insights into mitigating oxidative degradation in famotidine and other solid dosage forms, emphasizing the importance of selecting appropriate excipients, antioxidants, and predictive tools to ensure product stability. peroxides hydrogen peroxide famotidine chemical compounds Zeneth software peroksidi vodikov peroksid famotidin kemične spojine programska oprema Zeneth farmacevtska kemija oksidacija peroksidi true false true Angleški jezik Slovenski jezik Podatek o licenci CC BY-NC-ND 4.0 je naveden na pristajalni strani članka (glej zgoraj izvorni URL). (Datum opombe: 7. 11. 2025) Članek v reviji 2025-11-07 08:38:28 2025-11-07 08:38:34 2025-12-15 03:46:16 0000-00-00 00:00:00 2025 0 0 Str. 259-272 iss. 2 Vol. 75 Jun. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 543.2/.9:615.4:54 1846-9558 10.2478/acph-2025-0020 255015171 Impact_of_peroxide_content_in_excipients_and_antioxidants_on_famotidine_oxidative_stability_(3).pdf Impact_of_peroxide_content_in_excipients_and_antioxidants_on_famotidine_oxidative_stability_(3).pdf 1 3CEDA5F0C3CFC769447EFB5F0DCFC88D 35dc6e4c8b204f283b92bbf79f695504d5b0b10b9593915ae5af8cd8e1e1ea5c 4c129363-bbbd-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=221633 https://reference-global.com/article/10.2478/acph-2025-0020 1 72f2b572-bbac-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=221618 Fakulteta za farmacijo 0 0 0