20.500.12556/RUL-175598 Relationship between dietary pesticide intake and urinary excretion a pilot study using duplicate portion analysis Dietary uptake is estimated using residue data from food commodities and predicting the effect of food processing, such as peeling. The aim of this study was to explore the value of the analysis of duplicate portions supplemented by the analysis of urinary metabolites. Forty-three participants, consuming organic and non-organic diets collected a duplicate portion of food and beverages for 24 h. Urine was collected up to 36 h to account for metabolism and prolonged excretion of metabolites. Pesticide residues were analysed in food portions and urine samples using LC-MS/MS and GC-MS/MS. Multiple pesticide residues were detected per food portion. Out of 183 pesticides, 86 were detected in the diet. Glyphosate and AMPA were detected in 42 % and 30 % of all urine samples, respectively, while detection in the diet was low. A positive relationship between dietary intake and urinary excretion was found for 2,4-D and MCPA. No diet-urine relationship was observed for glyphosate and AMPA, indicating contribution from external routes of exposure. Hazard index (HI) indicated no exposure above the acceptable daily intake (ADI) for all participants. This study demonstrates how DPA combined with urine analysis gives insight into contribution of diet to total pesticide exposure compared to standard monitoring. plant protection products biocides biological monitoring dietary exposure fitofarmacevtska sredstva biocidi sredstva za varstvo rastlin prehranska izpostavljenost biološki monitoring true false true Angleški jezik Slovenski jezik Članek v reviji 2025-11-05 11:45:31 2025-11-05 11:45:37 2026-08-06 09:30:32 0000-00-00 00:00:00 2026 0 0 11 str. Vol. 164 art. 105972 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 61 0273-2300 10.1016/j.yrtph.2025.105972 255947523 1-s2.0-S0273230025002041-main.pdf 1-s2.0-S0273230025002041-main.pdf 1 870B76805A5838219689CF48750BB18A 05f52b9d56818fc66600e849dcd4d13c62db14477672cf995093388a5f298436 c76ca815-ba34-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=221389 https://www.sciencedirect.com/science/article/pii/S0273230025002041 1 4013a2c3-ba34-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=221388 Biotehniška fakulteta Medicinska fakulteta 0 0 0