20.500.12556/RUL-175591 The quinoline photoremovable group (PPG) platform - a medicinal chemist's approach for photocage development and applications Photoremovable protecting groups (PPGs) offer a straightforward solution for the temporary inactivation of biologically active substrates and their subsequent controlled release by light irradiation. Their relatively easy design and mode of application have made them useful tools for studying dynamic biological processes in vitro and in vivo. Recently, there has been a growing body of data investigating their potential application in the development of drug delivery systems. Of the various PPG scaffolds in use, quinoline photocages have a history of about 20 years. The structure-property relationships of quinoline PPGs, as well as alternative multibranch designs based on quinoline monomers have been thoroughly studied both experimentally and theoretically. Therefore, quinoline PPGs serve as a representative study of PPG development, showing how the various applications of quinoline photocages followed the chemical optimization or how the applications drove the chemical design. Since the raison d’être of PPGs lies in their application for light-activated release of various substrates or performing light-activated structural changes in materials, it is crucial to understand how PPGs are selected and utilized by their end-users, who are often not chemists themselves. Therefore, we discuss whether the conclusions drawn from the selected quinoline PPG family could lead to more general insights for the field as whole. As PPG-related applications still rely heavily on a limited number of chemical scaffolds, it is worth considering, what could be the reasons for the slow uptake of novel chemical scaffolds. drug delivery systems neuronal signaling photoremovable protecting groups quinoline photocages structure‐property relationships two‐photon absorption two‐photon uncaging nevronska signalizacija fotoodstranljive zaščitne skupine kinolinske fotokletke razmerja med strukturo in lastnostmi dvofotonska absorpcija dvofotonsko odstranjevanje iz škatle dostavni sistemi true false true Angleški jezik Slovenski jezik Članek v reviji 2025-11-05 09:27:56 2025-11-05 09:28:01 2025-12-12 03:55:39 0000-00-00 00:00:00 2024 0 0 Str. 1423-1451 iss. 5 Vol. 45 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 615.015.14 1098-1128 245245955 Medicinal_Research_Reviews_-_2025_-_Kontra_-_The_Quinoline_Photoremovable_Group__PPG__Platform_A_Medicinal_Chemist_s.pdf Medicinal_Research_Reviews_-_2025_-_Kontra_-_The_Quinoline_Photoremovable_Group__PPG__Platform_A_Medicinal_Chemist_s.pdf 1 7EA4321C53F42554E78EFDF7D9011BC3 64b4718e7ccc84d71fb4232a845c978fe1738aa9152eae21c92b69ae6828e6c4 84570b61-ba21-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=221365 https://onlinelibrary.wiley.com/doi/10.1002/med.22111 1 08fd80ff-ba21-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=221364 Fakulteta za farmacijo 0 0 0