20.500.12556/RUL-175397 Vpliv oblike mikrokanala na proces mešanja v mikrofluidičnem bioreaktorju Effect of microchannel shape on the mixing process in a microfluidic bioreactor Zaradi nizkega Reynoldsovega števila v mikrofluidnih sistemih je mešanje pogosto omejeno na počasno difuzijo, zato moramo za izboljšanje mešalnih sposobnosti geometrijo mikrokanala ustrezno manipulirati. V delu zasledujemo učinkovitost mešanja naslednjih petih geometrij mikrokanalov, to so kanal z ovirami oblike lune, cik-cak kanal, sinusoidni SAR kanal, heksagonalni SAR kanal in kanal s Teslinimi diodami, poleg tega raziskujemo tudi vpliv števila mešalnih sekcij na končno učinkovitost mešanja. Analiza je podkrepljena z ovrednotenjem tokovnega stanja v kanalu, pridobljenega z metodo PIV (angl. Particle Image Velocimetry). Geometrije mikrokanalov si po učinkovitosti mešanja na koncu kanala pri pretoku 1000 µl/min sledijo sledeče (od najslabšega do najboljšega): sinusoidni SAR, kanal z ovirami, heksagonalni SAR, kanal s Teslinimi diodami in cik-cak. Hitrostno polje in vrtinčnost kažeta na pomembnost oblik, ki promovirajo vrtinčenje in deljenje ter združevanje obeh tokov, sploh pri višjih vstopnih pretokih. Mikrofluidični sistemi, katerih bistvo je učinkovito mešanje vstopnih surovin, bodo v prihodnje v farmaciji in biotehnologiji igrali ključno vlogo za sintezo končnih učinkovin. Due to the low Reynolds number in microfluidic systems, mixing is often limited to slow diffusion, so we need to manipulate the microchannel geometry appropriately to improve mixing capabilities. In this work, we investigate the mixing efficiency of the following five microchannel geometries: a channel with moon-shaped obstacles, a zigzag channel, a sinusoidal SAR channel, a hexagonal SAR channel, and a channel with Tesla coils. In addition, we also investigate the influence of the number of mixing sections on the final mixing efficiency. The analysis is supported by an evaluation of the flow state in the channel, obtained using the PIV (Particle Image Velocimetry) method. The geometries of the microchannels are ranked according to their mixing efficiency at the end of the channel at a flow rate of 1000 μl/min as follows (from worst to best): sinusoidal SAR, channel with obstacles, hexagonal SAR, channel with Tesla coils, and zigzag. The velocity field and vorticity indicate the importance of shapes that promote vorticity and the separation and merging of both flows, especially at higher inlet flows. Microfluidic systems, whose essence is the efficient mixing of input raw materials, will play a key role in the synthesis of final active ingredients in the future of pharmaceuticals and biotechnology. mikrofluidika bioreaktor PIV 3D tiskanje hitrostno polje učinkovitost mešanja microfluidics bioreactor PIV 3D printing velocity field mixing efficiency true false false Slovenski jezik Angleški jezik Magistrsko delo/naloga 2025-10-25 08:30:27 2025-10-25 08:30:32 2025-12-10 03:48:24 0000-00-00 00:00:00 2025 0 0 XXI, 89 str. 2025 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 544.27:004.925.84(043.2) 277346 256153859 45486.pdf 45486.pdf 1 0B9D06AF256C3EAC71FDE23C6B6D4FA9 b7655b6e1264bfa0da459708fe316a222eb4d6add6858d91a7b7469819ca005b d1b0413b-b16b-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=220926 Fakulteta za strojništvo 0 0 0