20.500.12556/RUL-175229 Complexity and perplexity of pulsed field ablation an engineering perspective Pulsed field ablation (PFA), recently introduced as a non-thermal and selective method for cardiac ablation, was associated with great promise, hope and expectation, but also raised some concerns and left some questions unanswered, in particular with respect to waveform. To better understand the challenges associated with the design and development of safe and efficient PFA systems, the underlying mechanism of electroporation at the membrane, cellular and tissue levels is described. The three interdependent components of each system, that is, the waveform, the catheter and the generator, are then addressed. The effect of the different waveform parameters on treatment outcomes is reviewed, and the consequences of a potential mismatch of the three components in the development of a safe and efficient PFA system are highlighted. pulsed field ablation electroporation basics engineering perspective optimization development ablacija s pulznim električnim poljem osnove elekreopracije inženirski vidiki optimizacija razvoj true false true Angleški jezik Slovenski jezik Članek v reviji 2025-10-22 12:32:45 2025-10-22 12:32:48 2025-12-07 04:01:00 0000-00-00 00:00:00 2025 0 0 8 str. art. e24 Vol. 14 Jan. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 602.621:616.12-089.87 2050-3377 10.15420/aer.2025.37 254274563 AER_Miklavcic_WEB.pdf AER_Miklavcic_WEB.pdf 1 802D991F68B884F56C4A112AC2A967C9 29ed3f7ccd8db268bd7f2f5e6b168eaaa0288b684f22bd6eba65e7689d46e7a2 cd82bd2d-af32-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=220570 https://www.aerjournal.com/articles/complexity-and-perplexity-pulsed-field-ablation-engineering-perspective 1 2c5ba5eb-af32-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=220569 Fakulteta za elektrotehniko 0 0 0