20.500.12556/RUL-175116 Exposure of domestic cats (Felis catus) to rodenticidal compounds Anticoagulant rodenticides (ARs) are highly effective, but can be of environmental concern due to primary and secondary non-target exposure, with the latter possible being relevant to domestic cats. Therefore, liver residues of ARs and an alternative rodenticide, α-chloralose, were systematically monitored in domestic cats for the first time in the current study. In 2021 and 2022, the carcasses of 99 cats were collected in Slovenia and liver residues were measured by using solid supported liquid–liquid extraction and LC-MS/MS. The results show that 65% of cats carried at least one rodenticide. The second-generation ARs brodifacoum and bromadiolone were most prevalent and found in 53.5 and 25.3% of the samples, respectively. Of first-generation ARs, coumatetralyl was the most prevalent (21.2% of cats). More compounds were detected at high human population density, low farm density and in rural versus intermediate landscapes, but no effect was found for livestock density. Similar trends were found for the presence of brodifacoum, bromadiolone and all rodenticides combined. Farm density was negatively correlated with brodifacoum liver concentration. Individual factors (cat age, sex, outdoor activity) did not matter. The results indicate that a reasonably populated rural landscape, and not the rural or intermediate environment as such, is the main driver of cat exposure to ARs. The risk quotient (RQ) of worst-case acute brodifacoum poisoning was 1506. In summary, a potential environmental problem is globally highlighted for cats that is probably related to secondary exposure to ARs, with a pattern different to that seen in wild predators. Cats are an appropriate sentinel species for assessing rodenticide exposure and endangerment in the environment. anticoagulant toxicants α-chloralose domestic cats environmental monitoring mass spectrometry risk assessment true false true Angleški jezik Ni določen Članek v reviji 2025-10-17 04:43:19 2025-11-20 13:32:44 2025-12-06 03:50:47 0000-00-00 00:00:00 2025 0 0 18 str. iss 3, art. 663 Vol. 13 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 636.09:615.9 2305-6304 10.3390/toxics13080663 245364483 Exposure_of-Cerkvenik_Flajs.pdf Exposure_of-Cerkvenik_Flajs.pdf 1 9636ED19AC5194308C519CF71D5224DB f0ff741e5a83dbb3db54c66cc97bd40024863a0a0bd24b739fb711d4504d472e 40469900-ab47-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=220426 Veterinarska fakulteta Ekonomska fakulteta Biotehniška fakulteta 0 0 0