20.500.12556/RUL-175069 Določitev termičnih lastnosti hidrogelov na osnovi želatine za biomedicinske aplikacije Determination of the thermal properties of gelatine-based hydrogels for biomedical applications V diplomskem delu sem raziskal termične lastnosti posušenih štirih hidrogelov (kserogelov) in njihovih liofiliziranih različic z različnimi sestavami. Uporabljeni materiali za sintezo teh hidrogelov so bili želatina, kopolimer Pluronic F-127, fitinska kislina (PA) in taninska kislina (TA). Termične lastnosti sem preučeval z metodami TGMS, DSC, termooptometrijo in segrevanjem na grelni plošči. Različna razmerja izhodnih surovin v hidrogelih ter proces liofilizacije so vplivala na temperaturo pojava steklastega prehoda (T$_g$), termično stabilnost in obliko DSC krivulj. Liofilizirani vzorci so kazali pomembno manjši drugi endotermni vrh napram kserogelom. Na osnovi TG-MS meritev in signalov za vodo sem ga povezal z izločanjem le-te. Najboljše aplikativne lastnosti sta kazala hidrogel HG80, ki je vseboval vse zgoraj omenjene materiale v razmerju želatina:F-127:PA:TA = 3:2:1:0,1 in njegov liofilizat HG80-L, na katerima sem izvedel termooptično meritev in segrevanje na grelni plošči. Potrdil sem mehčanje vzorcev v temperaturnem območju steklastega prehoda, določenega z DSC, to je v telesno ugodnem temperaturnem območju med 40–50 °C. Ugotovitve prispevajo k razvoju nadaljnjih formulacij hidrogelov in razumevanju njihovih termičnih lastnosti. In my thesis, I investigated the thermal properties of four dried hydrogels (xerogels) and their lyophilized versions with different compositions. The materials used for the synthesis of these hydrogels were gelatin, Pluronic F-127 copolymer, phytic acid (PA), and tannic acid (TA). I studied the thermal properties using TG-MS, DSC, thermooptometry, and heating on a hot plate. The different ratios of the raw materials in the hydrogels and the lyophilization process influenced the glass transition temperature (T$_g$), thermal stability, and the shape of the DSC curves. The lyophilized samples showed a significantly smaller second endothermic peak compared to the xerogels. Based on TGMS measurements and the signals for water, I associated this peak with the release of water. The best applicative properties were shown by hydrogel HG80, which contained all the aforementioned materials in the ratio gelatin:F-127:PA:TA = 3:2:1:0.1, and its lyophilized form HG80-L, on which I performed thermo-optical measurements and heating on a hot plate. I confirmed the softening of the samples in the temperature range of the glass transition, as determined by DSC, that is, in the body-friendly temperature range between 40–50 °C. The findings contribute to the development of further hydrogel formulations and the understanding of their thermal properties. Kserogel hidrogel liofilizacija DSC TG-MS termooptometrija Xerogel hydrogel liofilisation DSC TG-MS thermooptometry true false false Slovenski jezik Angleški jezik Diplomsko delo/naloga 2025-10-14 13:10:01 2025-10-14 13:10:18 2025-12-03 04:04:49 0000-00-00 00:00:00 2025 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 25580 259098627 Breska_Tomaz_-_Dolocitev_termicnih_lastnosti_hidrogelov_na_osnovi_zelatine_za_biomedicinske_apli.pdf Breska_Tomaz_-_Dolocitev_termicnih_lastnosti_hidrogelov_na_osnovi_zelatine_za_biomedicinske_apli.pdf 1 C15006BEF1DAB8C0CA41FCD9950D867D d1c9bcddf3849f4db5e5a234319d33f727ca133b3bbbd8d5b12bc4fbbc6f183b 1c7365aa-a8ee-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=220076 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0