20.500.12556/RUL-175031 Razvoj in optimizacija sinteze alginatnih hidrogelov, zamreženih z bakrovimi ioni Development and optimization of synthesis of alginate hydrogels crosslinked with copper ions Alginat je naravni polisaharid, pridobljen z ekstrakcijo iz rjavih morskih alg, ki se pogosto uporablja za pripravo hidrogelov zaradi svoje biokompatibilnosti, biorazgradljivosti in netoksičnosti. Alginatni hidrogel, zamrežen z Cu$^{2+}$ ioni, ima širok spekter aplikacij, zlasti v farmaciji in (bio)medicini, saj baker izkazuje protimikrobne lastnosti. V okviru magistrske naloge smo razvili in optimizirali sintezo Cu-Alg hidrogelov z elektrodepozicijo na bakrovih elektrodah. Postopek smo optimizirali z vidika časa elektrodepozicije in gostote električnega toka. Ugotovili smo, da se koncentracija vezanega bakra v hidrogelu povečuje tako z daljšim časom kot tudi z višjo gostoto električnega toka. Določili smo ključne strukturne in mehanske lastnosti hidrogelov, kot je velikost polimerne mreže, strižni modul in gostoto zamreženja. Tako pripravljene Cu-alginatne hidrogele smo uporabili kot heterogene katalizatorje za modelno reakcijo cikloadicije. Uspešno smo prenesli klik kemijsko reakcijo iz šaržnega sistema na mikro-pretočni nivo, kjer smo dosegli visoko konverzijo reaktantov. Raziskava dokazuje, da je Cu-Alg hidrogel zaradi svojih strukturnih in funkcionalnih lastnosti primeren za uporabo v različnih tehnoloških in (bio)medicinskih aplikacijah. Alginate is natural polysaccharide extracted from brown seaweeds, widely used for hydrogel preparation due to its biocompatibility, biodegradability, and non-toxicity. Alginate hydrogel crosslinked with Cu$^{2+}$ ions exhibits a broad spectrum of potential applications, particularly in pharmacy and (bio)medicine, as copper demonstrates antimicrobial properties. In the framework of this master’s thesis, we developed and optimized the synthesis of Cu-Alg hydrogels by electrodeposition on copper electrodes. The process was optimized with respect to electrodeposition time and current density. We found that the concentration of coordinatively bound copper in the hydrogels increases with longer electrodeposition times as well as with higher current density. Furthermore, key structural and mechanical properties of the hydrogels were determined, including the degree of crosslinking, mesh size and crosslinking density. The prepared Cu-alginate hydrogels were further applied as heterogeneous catalysts for a model cycloaddition reaction. The click chemistry reaction was successfully transferred from the batch system to a microfluidic flow system, where high reactant conversion was achieved. This study demonstrates that Cu-Alg hydrogel, due to its structural and functional properties, is a promising for various technological and (bio)medical applications. hidrogel alginat elektrodepozicija mikropretočni sistem hydrogel alginate electrodeposition micro-continuous system true false false Slovenski jezik Angleški jezik Magistrsko delo/naloga 2025-10-14 11:05:01 2025-10-14 11:05:13 2025-12-03 03:48:17 0000-00-00 00:00:00 2025 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 24270 259111939 Ramsak_Arijana_-_Razvoj_in_optimizacija_sinteze_alginatnih_hidrogelov,_zamrezenih_z_bakrovimi_io.pdf Ramsak_Arijana_-_Razvoj_in_optimizacija_sinteze_alginatnih_hidrogelov,_zamrezenih_z_bakrovimi_io.pdf 1 A1944BB4005126C42F40C8FB5C2636D8 dbc86263ac386c84127ca45619675b823db9bc67babffa0391bc0471f822b717 a2cbd563-a8dc-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=219971 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0