20.500.12556/RUL-174483 Uvedba sistema za spremljanje okužb s Clostridioides (Clostridium) difficile na Onkološkem inštitutu magistrsko delo Implementation of the surveillance system for Clostridioides (Clostridium) difficile infections at the Institute of Oncology master thesis Uvod: Okužba povzročena s Clostridioides difficile je ena najpogostejših bolnišničnih okužb. Zaradi pomanjkanja standardiziranega spremljanja je Evropski center za preprečevanje in obvladovanje bolezni uvedel enoten protokol za evropske bolnišnice. Namen: Namen raziskave je bil vzpostaviti sistem za spremljanje okužb s Clostridioides difficile na Onkološkem inštitutu Ljubljana v skladu s protokolom Evropskega centra za preprečevanje in obvladovanje bolezni, izvesti enoletno pilotno spremljanje za leto 2023 ter primerjati podatke z evropskimi bolnišnicami. Metode dela: Zasnovani so bili elektronski vprašalniki, ki temeljijo na smernicah Evropskega centra za preprečevanje in obvladovanje bolezni. Spremljanje je obsegalo podrobno analizo potrjenih primerov: »okužba povzročena s Clostridioides difficile«, v letu 2023 in retrospektivni pregled podatkov od 2013 do 2022. Določeni so bili vključitveni, izključitveni in epidemiološki kriteriji. Rezultati: V letu 2023 je bilo na Onkološkem inštitutu Ljubljana ugotovljenih 24 primerov okužb povzročenih s Clostridioides difficile, od tega 66,7 % kot bolnišnične okužbe. Gostota incidence je znašala 4,6 primerov na 10.000 bolnišnično oskrbnih dni, incidenca pa 1,4 primera na 1000 odpustov. Analiza podatkov za obdobje do 2013 do 2022 je pokazala znatno nihanje incidence. Največ primerov je bilo leta 2015 in najmanj leta 2019. V zadnjih petih letih je bila pojavnost primerljiva. V primerjavi z bolnišnicami v državah Evropske unije ima Onkološki inštitut Ljubljana nižjo incidenco na 1000 odpustov, a višjo gostoto incidence na 10.000 bolnišnično oskrbnih dni. Razprava in zaključek: Uvedba sistema za spremljanje okužb povzročenih s Clostridioides difficile na Onkološkem inštitutu Ljubljana je bila uspešna. Elektronski vnos je povečal učinkovitost zbiranja podatkov. Onkološki bolniki zaradi svoje imunske oslabelosti predstavljajo skupino z večjim tveganjem za okužbo povzročeno s Clostridioides difficile. Za uspešno obravnavo okužb povzročenih s Clostridioides difficile v bolnišnici je pomembno sprotno zbiranje podatkov o pojavu okužb in dosledno izvajanje preventivnih ukrepov. Na Onkološkem inštitutu Ljubljana priporočamo nadaljnje spremljanje okužb povzročenih s Clostridioides difficile za izboljšanje kakovosti obravnave bolnikov in preprečevanje širjenja okužb. Introduction: Clostridioides difficile infection is among the most common healthcare-associated infections. Due to the lack of standardized surveillance systems in European hospitals, the European Centre for Disease Prevention and Control introduced a unified protocol to monitor Clostridioides difficile infection. Purpose: The aim of this master's thesis was to implement a Clostridioides difficile infection surveillance system at the Institute of Oncology Ljubljana in accordance with the European hospitals, the European Centre for Disease Prevention and Control protocol, conduct a one-year pilot surveillance for 2023, and compare the results with European data. Methods: Electronic data entry forms were developed based on European hospitals, the European Centre for Disease Prevention and Control forms. The study included detailed analysis of confirmed Clostridioides difficile infection cases for 2023 and a retrospective review of Clostridioides difficile infection data from 2013 to 2022. Inclusion and exclusion criteria were defined, as well as specific epidemiological definitions. Results: In 2023, 24 Clostridioides difficile infection cases were identified at Institute of Oncology Ljubljana, with 66.7% classified as healthcare-associated infections. The incidence density was 4.6 per 10,000 patient-days, and the incidence rate was 1.4 per 1,000 discharges. Data from 2013–2022 showed considerable variability, with the highest number of cases in 2015 and the lowest in 2019. Over the last five years, Clostridioides difficile infection occurrence has remained relatively stable. Compared to European Union/ European Economic Area hospitals, Institute of Oncology Ljubljana had a lower Clostridioides difficile infection incidence per 1,000 discharges but a higher incidence density per 10,000 patient-days. Discussion and Conclusion: The implementation of the Clostridioides difficile infection surveillance system at Institute of Oncology Ljubljana was successful. Electronic data collection improved efficiency and data quality. Oncology patients are at increased risk for Clostridioides difficile infection due to immunosuppression therapy. Continuous data collection and strict infection control measures are essential. Ongoing surveillance is recommended to improve patient care and prevent Clostridioides difficile infection transmission. magistrska dela zdravstvena nega Clostridioides difficile okužba s Clostridioides difficile bolnišnične okužbe epidemiološko spremljanje onkološki bolniki master theses nursing care Clostridioides difficile Clostridioides difficile infection healthcare-associated infections surveillance oncology patients true false false [D. Fon Glavan] Slovenski jezik Angleški jezik Magistrsko delo/naloga 2025-10-03 07:17:14 2025-10-03 07:17:18 2025-11-23 04:01:11 0000-00-00 00:00:00 2025 0 Ljubljana 0 Ljubljana 35 str., [10] str. pril. 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-083 153098 251578371 56753.pdf 56753.pdf 1 204D7F9EB8CF2DF966B77C66E80AECF3 8e020c661aaceff01aada2bbf3163a7ba250e8c4ca0b9005534fb44642e8c908 0808d6a9-a018-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=219302 Zdravstvena fakulteta 0 0 0