20.500.12556/RUL-173906 Povezava med zunajtelesno oploditvijo in prezgodnjim porodom diplomsko delo The association between in vitro fertilization and preterm birth diploma work Uvod: Zunajtelesna oploditev (IVF) predstavlja pomembno rešitev za neplodne pare, vendar številne raziskave opozarjajo na povečano tveganje za zaplete v nosečnosti, med katerimi je prezgodnji porod eden najresnejših. Po vsem svetu se število nosečnosti po IVF povečuje, zato je poznavanje povezanosti med IVF in prezgodnjim porodom ključno za klinično obravnavo teh nosečnic. Namen: Namen raziskave je bil preučiti povezavo med IVF in prezgodnjim porodom in ugotoviti, ali je IVF neodvisni dejavnik tveganja za prezgodnji porod tudi ob upoštevanju dejavnikov, ki lahko vplivajo tako na neplodnost kot na tveganje za prezgodnji porod. Metode dela: V prvem delu smo izvedli pregled literature, v drugem pa retrospektivno kohortno raziskavo z analizo podatkov iz Perinatalnega informacijskega sistema RS za obdobje 2013–2022. Uporabili smo deskriptivno in analitično statistiko, vključno z univariatno (Studentov T test in Hi kvadrat test) in multivariatno analizo (logistično regresijo). Za statistično značilno smo upoštevali vrednost p < 0,01. Rezultati: Analizirali smo 193.655 porodov, med katerimi je bilo 8646 nosečnosti po IVF. Ugotovili smo, da je nosečnost po IVF statistično značilno povezana z večjo verjetnostjo za prezgodnji porod (OR = 1,43; 95 % CI: 1,32–1,55; p < 0,001) in zelo prezgodnji porod (OR = 1,53; 95 % CI: 1,30–1,80; p < 0,001) tudi po prilagoditvi za potencialno moteče dejavnike. Nosečnice po IVF so bile pogosteje starejše, imele so višji indeks telesne mase in več pridruženih bolezni. Razprava in zaključek: IVF ostaja pomemben dejavnik tveganja za prezgodnji porod tudi ob upoštevanju dejavnikov, ki lahko vplivajo tako na plodnost kot na pojavnost prezgodnjega poroda. Glede na ugotovitve raziskave je treba nosečnosti po IVF obravnavati kot visoko tvegane ter zagotoviti individualizirano in poglobljeno predporodno obravnavo. Introduction: In vitro fertilization (IVF) has become an important solution for couples struggling with infertility; however, numerous studies have pointed to an increased risk of pregnancy complications, with preterm birth being among the most serious. As the number of IVF pregnancies rises globally, understanding the association between IVF and preterm birth is essential for clinical management of these pregnancies. Purpose: The aim of this study was to examine the association between IVF and preterm birth, and to determine whether IVF is an independent risk factor for preterm birth when accounting for other potential confounding variables. Methods: The first part of the thesis included a literature review, and the second part a retrospective cohort study with analysis based on data from the Slovenian Perinatal Information System fort he period 2013-2022. Descriptive and analytical statistics were used, including univariate and multivariate analysis. Results: A total of 193,655 births were analyzed, among which 8,646 pregnancies were conceived via IVF. The findings showed that IVF pregnancies were significantly associated with a higher risk of both preterm birth (OR = 1.43; 95% CI: 1.32–1.55; p < 0.001) and very preterm birth (OR = 1.53; 95% CI: 1.30–1.80; p < 0.001), even after adjustment for various confounders. IVF mothers were more likely to be older, have a higher body mass index, and have medical comorbidities. Discussion and conclusion: IVF remains an independent risk factor for preterm birth after statistical adjustment. Based on these results, IVF pregnancies should be considered high-risk and managed with individualized and enhanced prenatal care. diplomska dela babištvo zunajtelesna oploditev IVF oploditev z biomedicinsko pomočjo OBMP prezgodnji porod neplodnost dejavniki tveganja za prezgodnji porod neonatalni izidi po IVF diploma theses midwifery in vitro fertilization IVF medically assisted reproduction ART preterm birth infertility risk factors for preterm birth neonatal outcomes after IVF true false false [N. Hranjec] Slovenski jezik Angleški jezik Diplomsko delo/naloga 2025-09-25 07:45:42 2025-09-25 07:45:45 2025-11-15 03:47:55 0000-00-00 00:00:00 2025 0 Ljubljana 0 Ljubljana 32 str. 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 618.2/.7 152636 250326275 50570.pdf 50570.pdf 1 522838CC93E184EE530E1CC001F0413B 953cd83573ac8da85166839c152d067ad66f6cdaa6c8efd97aebdbf5e4833ca6 b108f63c-99d2-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=218594 Zdravstvena fakulteta 0 0 0