20.500.12556/RUL-173659 Pharmaceutical solid form screening and selection which form emerges? Solid form screening is an essential step in drug discovery and development because different solid forms of a drug substance may significantly affect the stability, dissolution, and/or manufacturing of the corresponding drug products. This paper takes up these issues, aiming to provide practical guidance on how to obtain and identify stable solid forms as well as validating proposed crystallization conditions in a set of representative active pharmaceutical ingredients (APIs). Techniques for solid form identification and characterization are discussed from the viewpoint of obtaining forms that are suitable for pharmaceutical development (e.g., physically/chemically stable, easily produced and manipulated on a large scale). Ten representative APIs are taken up for detailed study of their crystallization conditions. The forms are identified definitively using single-crystal X-ray diffraction methods. It is found that for all the APIs in this study, the proposed crystallization methods consistently yield the stable form, as previously identified in the literature. polymorph active pharmaceutical ingredients crystallization hydrogen bond polimorf aktivne farmacevtske učinkovine kristalizacija vodikova vez true false true Angleški jezik Slovenski jezik Članek v reviji 2025-09-19 12:38:38 2025-09-19 12:38:39 2025-10-13 04:06:46 0000-00-00 00:00:00 2025 0 0 Str. 4783-4794 iss. 13 Vol. 25 2 Jul. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 548.33:615 1528-7483 10.1021/acs.cgd.5c00252 246153987 chappa-et-al-2025-pharmaceutical-solid-form-screening-and-selection-which-form-emerges.pdf chappa-et-al-2025-pharmaceutical-solid-form-screening-and-selection-which-form-emerges.pdf 1 F3CB07FD5C85AF440C4A50D298BAB812 6031778e75affff2a4fa15e2568de19d2bd9006863481bb2fddbee9bd89cdcf8 8c3e526f-9545-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=218292 https://pubs.acs.org/doi/10.1021/acs.cgd.5c00252 1 a0a768e6-9544-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=218291 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0