20.500.12556/RUL-173430 Vpliv matrike pri PET slikanju diplomsko delo Matrix influence in PET imaging diploma work Uvod: Pozitronska emisijska tomografija (PET) predstavlja eno izmed najnaprednejbih metod sodobne slikovne diagnostike, saj omogo a zgodnje odkrivanje bolezni s prikazom presnovnih in biokemi nih procesov v telesu. V primerjavi z anatomskimi metodami, kot sta CT in MR, PET ponuja funkcionalni vpogled v delovanje organov, kar je klju no pri diagnostiki v onkologiji, nevrologiji in kardiologiji. Natan nost in kakovost PET slik sta odvisni od ve parametrov, med katerimi je velikost slikovne matrike eden klju nih dejavnikov. Ta vpliva na prostorsko lo ljivost, koli ino buma ter zanesljivost kvantitativnih meritev, kot je standardizirana vrednost privzema (SUV). Namen: Namen diplomskega dela je s sistemati nim pregledom literature raziskati vpliv velikosti slikovne matrike na kakovost in diagnosti no uporabnost PET slik. Osredoto ili sva se na vpliv matrike na rekonstrukcijo slik, prostorsko in kontrastno lo ljivost, pojav buma ter natan nost meritev standardne vrednosti privzema (SUV). Metode dela: Pri izdelavi diplomske naloge sva uporabili deskriptivno metodo s sistemati nim pregledom znanstvene in stokovne literature. Osredoto ili sva se na raziskave, izvedene na fantomih ali ljudeh, ki preu ujejo vpliv velikosti slikovne matrike pri PET slikanju. Literaturo sva iskali v anglebkem in slovenskem jeziku, predvsem v bazah Google U enjak, PubMed, ScienceDirect ter na spletnih straneh strokovnih ustanov. Uporabili sva dolo ene vklju itvene in izklju itvene kriterije, pri emer so bile klju ne tematska ustreznost, dostopnost in razumljivost lankov. Pregled literature je potekal med decembrom 2023 in majem 2025. Rezultati: Sistemati ni pregled devetih znanstvenih lankov, ki so obravnavali vpliv velikosti slikovne matrike na kakovost in diagnosti no uporabnost PET slik. Rezultati analiz ka~ejo, da pove anje velikosti matrike prispeva k boljbi prostorski lo ljivosti, vibjim SUV vrednostim ter izboljbani zaznavnosti majhnih lezij. Vendar pa to pogosto spremlja tudi pove anje buma in ve ja variabilnost kvantitativnih meritev, kar zahteva uporabo ustreznih filtrov in rekonstrukcijskih metod, kot sta PSF in BPL. Razprava in zaključek: Analizirane btudije so pokazale, da ve je matrike vodijo do vibjih SUV vrednosti in boljbe vizualne zaznave, a hkrati zahtevajo previdno interpretacijo zaradi mo~nosti la~no pozitivnih rezultatov. Slike z majhnimi voksli se izka~ejo za zanesljivejbe pri kvantifikaciji majhnih lezij, pri emer ohranjajo diagnosti no natan nost, e so pravilno filtrirane in obdelane. Velikost matrike mora biti vedno prilagojena cilju preiskave, anatomskemu podro ju in zmogljivostimi Sistema. Pravilno izbrana matrika, skupaj z ustrezno rekonstrukcijsko metodo, prispeva k boljbi detekciji, kvantifikaciji in tem kakovostnejbi obravnavi bolnikov. Introduction: Positron emission tomography (PET) is one of the most advanced methods in modern imaging diagnostics, as it enables early detection of diseases by visualizing metabolic and biochemical processes in the body. Compared to anatomical imaging techniques such as CT and MRI, PET provides a functional insight into organ activity, which is crucial for diagnostics in oncology, neurology, and cardiology. The accuracy and quality of PET images depend on several parameters, among which the size of the image matrix is a key factor. It affects spatial resolution, image noise, and the reliability of quantitative measurements such as the standardized uptake value (SUV). Purpose: The purpose of this thesis is to investigate, through a systematic literature review, the impact of image matrix size on the quality and diagnostic value of PET images. The focus is on how matrix size influences image reconstruction, spatial and contrast resolution, noise occurrence, and the accuracy of standardized uptake value (SUV) measurements. Methods: In this thesis, we used a descriptive method with a systematic review of scientific and professional literature. We focused on studies conducted on phantoms or human subjects that examined the influence of image matrix size in PET imaging. Literature was reviewed in both English and Slovenian, primarily using databases such as Google Scholar, PubMed, ScienceDirect, and official websites of professional institutions. Inclusion and exclusion criteria were applied, with emphasis on thematic relevance, accessibility, and comprehensibility of the articles. The literature review was conducted between December 2023 and May 2025. Results: A systematic review of nine scientific studies examining the impact of image matrix size on the quality and diagnostic utility of PET images. The analyses showed that increasing the matrix size contributes to improved spatial resolution, higher SUV values, and enhanced detectability of small lesions. However, this often comes at the cost of increased image noise and greater variability in quantitative measurements, necessitating the use of appropriate filtering and reconstruction methods such as PSF and BPL. Discussion and conclusion: The analyzed studies demonstrated that larger matrices result in higher SUV values and better visual detection but require careful interpretation due to the potential for false-positive findings. Images with smaller voxels proved more reliable in quantifying small lesions while maintaining diagnostic accuracy when properly filtered and processed. The matrix size should always be tailored to the objective of the examination, the anatomical region, and the capabilities of the system. A properly selected matrix, in combination with an appropriate reconstruction method, enhances lesion detection, quantification, and overall quality of patient care. diplomska dela radiološka tehnologija pozitronska emisijska tomografija (PET) slikovna matrika nuklearna medicina prostorska lo ljivost standardna vrednost privzema (SUV) rekonstrukcija slik kakovost slike diploma theses radiologic technology positron emission tomography (PET) image matrix nuclear medicine spatial resolution standardized uptake value (SUV) image reconstruction image quality true false false [I. Lipovac Bošnik : T. Petrović] Slovenski jezik Angleški jezik Diplomsko delo/naloga 2025-09-17 08:50:38 2025-09-17 08:50:41 2025-11-09 03:42:25 0000-00-00 00:00:00 2025 0 Ljubljana 0 Ljubljana 38 str. 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-07 150436 249240067 53330.pdf 53330.pdf 1 376EB31A714E9A983E410841F21408A7 3a2996931dfc6986a76accfb21bdc6449780e83b82dbdc995e265270536248c6 73c3dd32-9392-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=217840 Zdravstvena fakulteta 0 0 0