20.500.12556/RUL-173429 Prispevek SPECT/CT scintigrafije skeleta pri pacientih z osteosintetskim materialom magistrsko delo Contribution of SPECT/CT bone scintigraphy in patients with osteosynthetic material master thesis Uvod: Osteointegracija in uporaba osteosintetskega materiala predstavljata pomembna področja v ortopediji in travmatologiji. Zaradi komplikacij, kot so okužbe, ohlapnost implantatov in neustrezna integracija, so slikovne metode ključnega pomena. SPECT/CT scintigrafija skeleta združuje funkcionalne in anatomske informacije ter omogoča bolj natančno vizualizacijo sprememb v kostnem tkivu v primerjavi s klasično scintigrafijo ali radiološkimi preiskavami. Namen: Glavni cilj raziskave je bil oceniti diagnostično vrednost SPECT/CT scintigrafije pri pacientih z osteosintetskim materialom. Preučili smo vpliv različnih rekonstrukcijskih algoritmov na kakovost slik in analizirali njihovo uporabnost pri prepoznavanju patoloških sprememb. Poleg tega smo SPECT/CT primerjali z drugimi slikovnimi metodami, z namenom ugotavljanja prednosti in omejitev. Metode dela: V raziskavo so bili vključeni pacienti, ki so imeli vgrajen osteosintetski material in so opravili SPECT/CT preiskavo, zaradi suma na komplikacije. Analizirali smo diagnostične parametre, kot so kontrastnost slike ter vpliv različnih algoritmov na kvaliteto rekonstrukcije slik. Poleg tega smo izvedli primerjalno analizo SPECT/CT s tradicionalnimi metodami ter ocenili klinično uporabnost rezultatov. Rezultati: Rezultati so pokazali, da je SPECT/CT scintigrafija znatno izboljšala diagnostiko pri pacientih z osteosintetskim materialom. Metoda je omogočila natančnejšo vizualizacijo področij povečane metabolne aktivnosti, kar je bilo ključnega pomena pri diferenciaciji med vnetnimi in degenerativnimi procesi. Uporaba naprednih algoritmov, kot je xBONE, je izboljšala kontrast in ostrino slik, kar je pripomoglo k boljši prepoznavnosti patoloških sprememb. V primerjavi z običajno scintigrafijo je SPECT/CT omogočil večjo natančnost in specifičnost pri oceni stanja implantatov. Razprava in zaključek: Na podlagi rezultatov raziskave lahko zaključimo, da ima SPECT/CT pomembno vlogo pri diagnostiki komplikacij pri pacientih z osteosintetskim materialom. Združevanje funkcionalnih in anatomskih informacij omogoča boljše razlikovanje med patološkimi in fiziološkimi procesi, ter pripomore k natančnejšemu načrtovanju zdravljenja. Napredni rekonstrukcijski algoritmi dodatno izboljšujejo kakovost slik, kar še povečuje diagnostično vrednost metode. SPECT/CT tako predstavlja pomembno dopolnilo klasičnim slikovnim metodam in se vse bolj uveljavlja kot standard v klinični praksi. Introduction: Osseointegration and the use of osteosynthetic material represent important areas in orthopedics and traumatology. Imaging techniques play a crucial role in diagnosing complications such as infections, implant loosening, and inadequate integration. SPECT/CT bone scintigraphy combines functional and anatomical information, providing more precise visualization of bone tissue changes compared to conventional scintigraphy or radiological examinations. Purpose: The main objective of this study was to evaluate the diagnostic value of SPECT/CT scintigraphy in patients with osteosynthetic material. We examined the impact of different reconstruction algorithms on image quality and analyzed their usefulness in detecting pathological changes. Additionally, we compared SPECT/CT with other imaging modalities such as conventional scintigraphy. Methods: The study included patients with implanted osteosynthetic material who underwent SPECT/CT examinations due to suspected complications. We analyzed diagnostic parameters such as image contrast, sensitivity, specificity, and the effect of different reconstruction algorithms on image quality. A comparative analysis of SPECT/CT with traditional imaging methods was conducted to evaluate its clinical applicability. Results: The results showed that SPECT/CT scintigraphy significantly improved diagnostics in patients with osteosynthetic material. The method provided more accurate visualization of areas with increased metabolic activity, which was essential for differentiating between inflammatory and degenerative processes. The use of advanced reconstruction algorithms, like xBONE, enhanced image contrast and sharpness, contributing to better recognition of pathological changes. Compared to conventional scintigraphy, SPECT/CT demonstrated higher accuracy and specificity in assessing implant conditions. Discussion and conclusion: Based on the study results, we conclude that SPECT/CT plays an important role in diagnosing complications in patients with osteosynthetic material. The combination of functional and anatomical information allows for better differentiation between pathological and physiological processes, contributing to more precise treatment planning. Advanced reconstruction algorithms further improve image quality, increasing the diagnostic value of the method. SPECT/CT is becoming an essential supplement to conventional imaging techniques and is increasingly recognized as a standard in clinical practice. magistrska dela radiološka tehnologija SPECT/CT osteosintetski material scintigrafija skeleta diagnostična vrednost rekonstrukcijski algoritmi master's theses radiologic technology SPECT/CT osteosynthetic material bone scintigraphy diagnostic value reconstruction algorithms true false false [S. Belšak] Slovenski jezik Angleški jezik Magistrsko delo/naloga 2025-09-17 08:50:33 2025-09-17 08:50:37 2025-11-09 03:42:06 0000-00-00 00:00:00 2025 0 Ljubljana 0 Ljubljana 45 str. 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-07 150435 249222915 53238.pdf 53238.pdf 1 D7D53046B9A3045388C4614E5C2DCF74 f274d9bfca522ab915943f06a1dba044e563437b800ebbbe7770c0c58f18757e 7145049b-9392-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=217839 Zdravstvena fakulteta 0 0 0