20.500.12556/RUL-172915 Bio-proizvodnja zdravil, cepiv in industrijskih izdelkov na rastlinski osnovi Bio-production of plant based medicines, vaccines and industrial products Rastlinska bio-proizvodnja predstavlja hitro razvijajoče se področje biotehnologije, ki uporablja rastline kot platformo za sintezo zdravil, cepiv in industrijskih izdelkov. Že tradicionalno pomembne, kot vir naravnih zdravil, so rastline danes vse bolj prepoznane kot trajnostna, varna in stroškovno učinkovita alternativa klasičnim proizvodnim sistemom, kot so bakterije, kvasovke in sesalske celične linije. Glavne prednosti rastlinskih sistemov vključujejo možnost evkariontskih post-translacijskih modifikacij, nizko tveganje za kontaminacijo s patogeni ter enostavno prilagoditev na večje proizvodne skale. Kljub številnim prednostim se tehnologija sooča s tehničnimi, regulativnimi in družbenimi izzivi, kot so nizke koncentracije učinkovin, kompleksna standardizacija procesov ter javna percepcija gensko spremenjenih rastlin. V prihodnosti bo ključno nadaljnje raziskovanje genetskih orodij, razvoj stabilnih rastlinskih celičnih kultur in integracija digitalnih tehnologij v proizvodne procese. Rastlinska bio-proizvodnja tako ni več zgolj obetavna možnost, temveč vse bolj uveljavljena komponenta sodobne bioprodukcije, ki prispeva k trajnostnemu razvoju, izboljšanju globalne dostopnosti zdravil in zmanjšanju okoljskega vpliva. Plant-based bioproduction represents a rapidly developing field of biotechnology that utilizes plants as platforms for the synthesis of pharmaceuticals, vaccines, and industrial products. Traditionally important as a source of natural medicines, plants are now increasingly recognized as a sustainable, safe, and cost-effective alternative to conventional production systems such as bacteria, yeast, and mammalian cell lines. The main advantages of plant-based systems include the ability to perform eukaryotic post-translational modifications, low risk of pathogen contamination, and easy scalability for large-scale production. Despite numerous advantages, the technology faces technical, regulatory, and societal challenges, including low concentrations of active compounds, complex process standardization, and public perception of genetically modified plants. Future progress will depend on further research into genetic tools, the development of stable plant cell cultures, and the integration of digital technologies into production processes. Plant-based bioproduction is therefore no longer just a promising option but is becoming an increasingly established component of modern biomanufacturing, contributing to sustainable development, improved global access to medicines, and reduced environmental impact. Rastlinska bio-proizvodnja gensko spremenjene rastline Agrobacterium tumefaciens trajnostna proizvodnja Plant bio-production genetically modified plants Agrobacterium tumefaciens sustainable production true false false Slovenski jezik Angleški jezik Diplomsko delo/naloga 2025-09-12 07:18:33 2025-09-12 07:18:35 2025-10-28 03:39:51 0000-00-00 00:00:00 2025 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 263654 249399299 51213.pdf 51213.pdf 1 E4B3773E3F997CBFCB50619948A5AB68 b037eb5d58ac67bade7fb0a8ae2f280cc73aac22a84faecf592ed46ad402567e c449cc4b-8f97-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=217049 Biotehniška fakulteta 0 0 0