20.500.12556/RUL-172914 Alternativna poliadenilacija kot mehanizem uravnavanja izražanja genov v odzivu na stres pri rastlinah Alternative polyadenylation as a mechanism for regulating gene expression in response to stress in plants Alternativna poliadenilacija (APA) predstavlja pomemben mehanizem posttranskripcijske regulacije izražanja genov pri rastlinah. V diplomski nalogi so predstavljeni osnovni molekularni mehanizmi APA in njen vpliv na stabilnost mRNA, učinkovitost translacije ter nastanek funkcionalno različnih proteinskih izoform. Poseben poudarek je namenjen vlogi APA v odzivu rastlin na abiotski in biotski stres, kot so suša, hipoksija, saliniteta, nizke temperature in okužbe s patogeni. Pregled sodobnih raziskav kaže, da APA omogoča hitro in prilagodljivo spremembo transkriptoma, kar rastlinam zagotavlja učinkovitejši odziv na neugodna okolja brez sprememb v genetskem zapisu. Zaradi svoje vloge pri povečanju stabilnosti mRNA in pospeševanju sinteze zaščitnih proteinov ima APA velik potencial za uporabo v agronomiji, zlasti pri razvoju rastlin, odpornih na podnebne spremembe in stresne razmere. Alternative polyadenylation (APA) represents an important mechanism of post-transcriptional regulation of gene expression in plants. This review focuses on the basic molecular mechanisms of APA and its impact on mRNA stability, translation efficiency, and the formation of functionally diverse protein isoforms. Special emphasis is placed on the role of APA in plant responses to abiotic and biotic stresses, such as drought, hypoxia, salinity, low temperatures, and pathogen infections. Recent research shows that APA enables rapid and flexible changes to the transcriptome, allowing plants to respond more effectively to unfavorable environmental conditions without alterations in the genetic sequence. Due to its role in enhancing mRNA stability and accelerating the synthesis of protective proteins, APA holds great potential for applications in agronomy, particularly in the development of plants resistant to climate change and stress conditions. alternativna poliadenilacija genska ekspresija abiotski stres biotski stres regulacija mRNA rastline alternative polyadenilation gene expression abiotic stress biotic stress mRNA regulation plants true false false Slovenski jezik Angleški jezik Diplomsko delo/naloga 2025-09-12 07:18:31 2025-09-12 07:18:32 2025-10-28 03:38:44 0000-00-00 00:00:00 2025 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 263653 249394179 51242.pdf 51242.pdf 1 A40D4218449D0EDD1EB08F6BF94A3005 26aa7b3e8f1749ef7f8b061af0eab721fe1a5110ce1e0da54c1e8236e0c2283f c2a597af-8f97-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=217048 Biotehniška fakulteta 0 0 0