20.500.12556/RUL-172602 Dietary patterns and blood-based biomarkers of Alzheimer’s disease in cognitively intact older adults findings from a population-based study Background: Diet can impact cognitive aging, but comprehensive data from human studies is lacking and the underlying biological mechanisms are still not fully understood. Objectives: To investigate the associations between two dietary patterns consistently linked to inflammation and brain health [the Mediterranean diet (MDS) and inflammatory potential of diet (EDII)] and five blood-based biomarkers of Alzheimer´s disease (AD) in a sample of dementia-free community-dwelling older adults. Design and setting: We used cross-sectional data from the Swedish National Study on Aging and Care in Kungsholmen (SNAC-K). Participants: Participants who were institutionalized, had dementia or Parkinson’s disease, or had missing data on diet and/or biomarkers were excluded. Our study sample consisted of 1907 adults ≥60 years old. Measurements: Adherence to the MDS and EDII was assessed using a validated food frequency questionnaire. Ttau, p-tau181, A 42/40, NfL, and GFAP were measured in serum. associations were estimated through quantile regression models at the 25th, 50th, and 75th percentiles of the biomarkers’ levels, and were adjusted for potential confounders and stratified by sex, age, and APOE-e4 genotype. Results: In the whole sample, higher adherence to the MDS was associated with lower levels of p-tau181 at the 50th and 75th percentiles [(95% CI) per 1-SD increment = -0.028 (-0.053, -0.002) and -0.036 (-0.072, -0.001), respectively], while higher adherence to the EDII was associated with higher levels of NfL at the 75th percentile [(95% CI) per 1-SD increment =0.031 (0.008, 0.053)]. Associations with other biomarkers were only apparent at lower levels of their distribution. Subgroup analyses showed: 1) a stronger inverse association between the MDS and p-tau181 in APOE-e4 carriers than non-carriers, and 2) an inverse association of the MDS with GFAP only in participants ≥78 years. Conclusions: Diet seems to be associated with biomarkers of AD pathology in cognitively intact older adults. Some associations were more apparent in the presence of genetic predisposition for AD or advanced age. neurodegeneration total tau phosphorylated tau amyloid beta neurofilament light glial fibrillary acidic protein diet quality mediterranean diet cohort study dementia prevention prehrana ljudi Alzheimerjeva bolezen biomarkerji true false true Angleški jezik Slovenski jezik Članek v reviji 2025-09-09 14:27:40 2025-09-09 14:27:42 2026-01-06 08:22:11 0000-00-00 00:00:00 2025 0 0 10 str. issue 6, [article no.] 100124 Vol. 12 Jun. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2025-03-14 613.2 2426-0266 10.1016/j.tjpad.2025.100124 248270339 RAZ_Mrhar_Anja_2025.pdf RAZ_Mrhar_Anja_2025.pdf 1 DA7C848B763269B2C8AABB9683042460 dc2d58d08ffab6d4f6a9a8513560174194f5c18f69e6e83de357374ffa37e3de 4cf92d8e-d990-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=223695 https://www.sciencedirect.com/science/article/pii/S2274580725000688 0 20c64159-ead0-11f0-bf92-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=224989 Biotehniška fakulteta 0 0 0