20.500.12556/RUL-172520 Razvoj naprednih hidrogelov za pametne dostavne sisteme biofarmacevtskih učinkovin Development of advanced hydrogels for smart delivery systems of biopharmaceutical agents Hidrogeli so tridimenzionalne polimerne mreže, ki zadržujejo velike količine vode in zaradi svojih mehkih in tkivom podobnih lastnosti veljajo za eno najbolj obetavnih vrst biomaterialov. Njihova edinstvena prednost je v sposobnosti, da zagotavljajo mehansko podporo, hkrati pa shranjujejo in postopoma sproščajo bioaktivne spojine. Hidrogel se zaradi posnemanja naravnega ekstracelularnega okolja vse pogosteje uporablja kot nosilec za ciljno dostavo terapevtskih sredstev, zlasti makromolekul, ki so občutljive na razgradnjo. To delo poudarja fizikalno-kemijske mehanizme, ki so osnova delovanja hidrogelov, vključno s teorijama Flory-Huggins in Flory-Rehner ter konceptom prostega volumna. Ti parametri so tesno povezani z dinamiko difuzije in sproščanja zdravil, kar omogoča oblikovanje materialov z natančno prilagojenimi profili sproščanja. Posebna pozornost je namenjena temperaturi steklastega prehoda, velikosti hidrogelne mreže in njihovemu vplivu na kontrolirano sproščanje. Nedavni napredek je prinesel novo generacijo hidrogelov, kot so na dražljaje odzivni, samoorganizirajoči se peptidi, nanokompozitni in hibridni sistemi, ki združujejo prednosti različnih razredov materialov. Poleg tradicionalnih pristopov, ki vključujejo kemično in fizikalno zamreženje, pridobivajo na pomenu sodobne tehnike, kot je 3D biotiskanje, ki omogočajo natančno izdelavo prilagojenih, funkcionalno razvrščenih struktur in tako premostijo vrzel med konceptualnim oblikovanjem in dejansko uporabo. Biomedicinska pomembnost hidrogelov je prikazana z uporabo v regenerativni medicini in farmacevtskem dajanju zdravil, od regeneracije živčnega in srčnega tkiva do ciljnega sproščanja zdravil v prebavnem traktu skozi kožno pregrado. Širše gledano delo vključuje pregled literature ter prikazuje, kako lahko medsebojno delovanje kemije, fizike in inženirski strategij privede do »pametnih« hidrogelnih sistemov, ki utirajo po varnejšim, učinkovitejšim in bolnikom prijaznejšim terapevtskim rešitvam. Hydrogels are three-dimensional polymeric networks that retain large amounts of water and, due to their soft and tissue-like properties, are considered one of the most promising classes of biomaterials. Their unique advantage lies in the ability to provide mechanical support while simultaneously storing and gradually releasing bioactive compounds. By mimicking the natural extracellular environment, hydrogels are increasingly used as carriers for the targeted delivery of therapeutics, particularly macromolecules that are sensitive to degradation. This work emphasizes the physicochemical mechanisms underlying hydrogel performance, including the Flory-Huggins and Flory-Rehner theories as well as the concept of free volume. These parameters are closely linked to diffusion and drug-release dynamics, enabling the design of materials with finely tuned release profiles. Special attention is given to glass transition temperature, mesh size, and their impact on controlled release. Recent advances have introduced a new generation of hydrogels, such as stimuli-responsive, self-assembling peptide-based, nanocomposite, and hybrid systems that combine the strengths of different material classes. Alongside traditional approaches involving chemical and physical crosslinking, modern techniques such as 3D bioprinting are gaining importance, offering precise fabrication of customized, functionally graded structures and thus bridging the gap between conceptual design and real-world application. The biomedical relevance of hydrogels is illustrated through applications in regenerative medicine and pharmaceutical delivery, ranging from neuro- and cardiac tissue regeneration to targeted drug release within the gastrointestinal tract or across the skin barrier. More broadly, the work includes a review of the literature and demonstrates how the interplay of chemistry, physics, and engineering strategies can give rise to "smart" hydrogel systems that pave the way toward safer, more effective, and patient-friendly therapeutic solutions. hidrogeli dostavni sistemi biofarmacevtika 3D biotiskanje hydrogels drug delivery systems biopharmaceuticals 3D bioprinting true false false Slovenski jezik Angleški jezik Diplomsko delo/naloga 2025-09-08 10:00:00 2025-09-08 10:00:12 2025-10-29 10:59:16 0000-00-00 00:00:00 2025 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 25795 255204611 Peterka_Tilen_-_Razvoj_naprednih_hidrogelov_za_pametne_dostavne_sisteme_biofarmacevtskih_ucinkov.pdf Peterka_Tilen_-_Razvoj_naprednih_hidrogelov_za_pametne_dostavne_sisteme_biofarmacevtskih_ucinkov.pdf 1 3C60E5497BDC8761ED11953EEA29D660 414cafb522774f2a22a8717af853828443bd70a50f83095790a8fc2fd989b832 b1db868e-8c89-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=216348 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0