20.500.12556/RUL-171917 Detekcija stopenj sušenja pri procesu liofilizacije v viali na nivoju laboratorijskega testiranja Detection of drying stages during lyophilization in a vial at the laboratory scale V diplomski nalogi je bila obravnavana detekcija stopenj sušenja pri procesu liofilizacije v viali na nivoju laboratorijskega testiranja. Z uporabo merilnika gostote toplotnega toka je bilo mogoče v realnem času spremljati prehode med posameznimi fazami sušenja in natančno določiti njihov konec. Rezultati so pokazali, da ustrezna detekcija konca posamezne faze sušenja omogoča skrajšanje celotnega sušilnega cikla za približno 10 ur in posledično prihranek energije do 34 % glede na celoten cikel, brez negativnega vpliva na kakovost končnega izdelka. Poleg tega raziskava potrjuje, da je laboratorijsko testiranje pomembno za razvoj in optimizacijo procesnih parametrov, ki jih je možno kasneje prenesti tudi na industrijski nivo. In the diploma thesis, the detection of drying stages in the lyophilization process in a vial at the laboratory testing level was studied. Using a heat flux meter, it was possible to monitor the transitions between individual drying phases in real time and accurately determine their end. The results showed that appropriate detection of the end of each drying phase enables a reduction of the total drying cycle by approximately 10 hours and consequently an energy saving of up to 34 % over the entire cycle, without any negative impact on the quality of the final product. In addition, the research confirms that laboratory testing is important for the development and optimization of process parameters, which can later be transferred to the industrial level. detekcija stopenj sušenja liofilizacija zamrzovalno sušenje laboratorijsko testiranje merilnik gostote toplotnega toka detection of drying stages lyophilization freeze-drying laboratory testing heat flux sensor true false false Slovenski jezik Angleški jezik Diplomsko delo/naloga 2025-09-04 08:32:27 2025-09-04 08:32:27 2025-09-26 03:49:03 0000-00-00 00:00:00 2025 0 0 XX, 44 str. 2025 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 66.047.3.049.6:001.891.53(043.2) 275382 248581379 43395.pdf 43395.pdf 1 E7B6D3E1D08E03965C1D74B4D4129492 5e26231d78be3fb17c631792ea4274bb60fc38e0a992e0d94761be07cd0b1e5d c71a3dcd-8958-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=215485 Fakulteta za strojništvo 0 0 0