20.500.12556/RUL-171893 Vpliv pozicije viale v liofilizatorju na proces liofilizacije Effect of vial position in a lyophilizer on the lyophilization process V nalogi smo obravnavali vpliv pozicije viale na polici laboratorijskega liofilizatorja na potek procesa liofilizacije. Vialo s 5 % masnim deležem saharoze v vodni raztopini smo postavili na šest različnih mest na grelno-hladilno polico liofilizatorja. Spremljali smo temperaturo viale in temperaturo ter gostoto toplotnega toka na stiku viale s polico med zamrzovanjem, primarnim sušenjem in sekundarnim sušenjem. Rezultati so pokazali razpon trajanja primarnega sušenja od 6,60 h do 7,20 h med posameznimi pozicijami vial, kar potrjuje nehomogenost temperaturnega polja na polici laboratorijskega liofilizatorja. Na osnovi izvedene analize predlagamo, da se za natančnejšo določitev časa primarnega sušenja za vsak liofilizator določi najmanj ugodno mesto, ki je najbolj izpostavljeno zunanjim vplivom in s tem izkazuje najdaljši čas primarnega sušenja. In this work, the the influence of the position of the vial on the shelf of a laboratory lyophilizer on the lyophilization process was examined. A vial with a 5% mass fraction of sucrose in an aqueous solution was placed in six different places on the heating-cooling shelf of the lyophilizer. The temperature of the vial and the temperature and heat flux at the contact of the vial with the shelf were monitored during freezing, primary drying and secondary drying. The results showed a range of primary drying duration from 6,60 h to 7,20 h between individual vial positions, which confirms the inhomogeneity of the temperature field on the shelf of the laboratory lyophilizer. Based on the analysis performed, we propose that, in order to more accurately determine the primary drying time, the least favorable location should be determined for each lyophilizer, which is most exposed to external influences and thus exhibits the longest primary drying time. liofilizacija viala primarno sušenje sekundarno sušenje pozicija viale lyophilization vial primary drying secondary drying vial position true false false Slovenski jezik Angleški jezik Diplomsko delo/naloga 2025-09-04 08:30:40 2025-09-04 08:30:42 2025-09-24 04:04:41 0000-00-00 00:00:00 2025 0 0 XX, 50 str. 2025 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 536.5:66.047.3:57.086.13(043.2) 275358 248527875 43371.pdf 43371.pdf 1 9581CB6D4CEB2588E018C69187CEF39C bd6057144a86d43ac304c7b8a8f02eaedd85b03d8c10c46351500eefaa753e16 885933a3-8958-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=215459 Fakulteta za strojništvo 0 0 0