20.500.12556/RUL-171835 Pregled kozmetično aktivnih sestavin z retinolu podobnim delovanjem Overview of cosmetically active ingredients with retinol-like action Retinol ter ostali retinoidi, se zaradi svojega širokega spektra delovanja tako na aknasto kot tudi starano kožo, vključujejo v številne kozmetične izdelke. Kljub visoki učinkovitosti pa njihovo uporabo omejuje pojav nezaželenih učinkov, kot sta draženje in eritem. Zato se med potrošniki povečuje zanimanje za alternativne kozmetično aktivne sestavine, ki bi zagotavljale primerljivo učinkovitost ob boljši kožni toleranci. V okviru diplomske naloge smo s pomočjo spletne platforme Global Cosmetic Industry naredili pregled šestih kozmetično aktivnih sestavin, ki se oglašujejo kot alternative retinolu: Revinage, NovoRetin, bakučiol, BakuLipid, Bakusylan in Stevisse. Te sestavine retinolu podobno delovanje izkazujejo preko funkcionalne ali strukturne podobnosti ali pa preko različnih mehanizmov pripomorejo k večji količini naravno prisotne retinojske kisline v koži. V pregledanih kliničnih raziskavah so izbrane sestavine izkazovale rezultate, primerljive z retinoidi. Ker pa je bila večina študij izvedena s strani proizvajalcev, ostajajo pomisleki o morebitni pristranskosti rezultatov. Alternative se zaradi svoje fotostabilnosti in dobre tolerance lahko uporabljajo pogosteje kot retiniodi, tudi dvakrat dnevno. Pri analizi kozmetičnih izdelkov na trgu z izbranimi kozmetično aktivnimi sestavinami, jih je bilo največ vključenih v kozmetične izdelke za nego kože, predvsem v serume. Na tržišču smo našli tudi kozmetične izdelke z vgrajenimi večimi alternativami retinoidom ter tudi kombinacije alternativ retinoidov z retinoidi. Alternative retinoidov v takšnih kombinacijah lahko delujejo sinergistično in omogočijo uporabo nižjih koncentracij kozmetično aktivnih sestavin, kar posledično zmanjšuje verjetnost pojava neželenih učinkov. Nekatere izmed njih s svojim antioksidativnim delovanjem dodatno prispevajo k večji stabilnosti retinoidov v formulacijah. Retinols and other retinoids are widely incorporated into various cosmetic products due to their broad-spectrum efficacy in addressing both acne-prone and aging skin. Despite their proven effectiveness, their use is often limited by undesirable side effects, such as irritation and erythema. As a result, consumer demand for alternative cosmetically active ingredients with similar efficacy and enhanced skin tolerance is on the rise. In the thesis, we conducted a review of six cosmetically active ingredients marketed as retinol alternatives, using the online platform Global Cosmetic Industry. The selected ingredients were: Revinage, NovoRetin, bakuchiol, BakuLipid, Bakusylan, and Stevisse. These ingredients exhibit retinol-like activity either through functional or structural similarity or by promoting increased levels of naturally occurring retinoic acid via different mechanisms. In the reviewed clinical studies, these alternatives demonstrated results comparable to retinoids. However, since most of the studies were conducted by manufacturers, concerns regarding potential bias in the reported outcomes remain. Due to their improved photostability and skin tolerance, these alternatives can be applied twice daily, whilst retinoids can only be applied once. Our market analysis of cosmetic products containing these ingredients revealed that they are most commonly incorporated into skincare formulations, particularly serums and creams. Additionally, several products on the market were found to combine multiple retinoid alternatives, or to include such alternatives alongside conventional retinoids. Such formulations may provide synergistic effects, enabling the use of lower concentrations of actives while maintaining efficacy and reducing the likelihood of side effects. Furthermore, some of the ingredients contribute to the increased stability of retinoids in formulations due to their antioxidant properties. retinoidi retinol bakučiol analiza trga retinoids retinol bakuchiol market analysis true false false Slovenski jezik Angleški jezik Diplomsko delo/naloga 2025-09-03 08:45:23 2025-09-03 08:45:25 2025-09-22 03:48:46 0000-00-00 00:00:00 2025 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 1970-01-01 117124 28277.pdf 28277.pdf 1 000C8703555FCAB69A6C740216000FD2 69807c0fca0200a591f93e14495fd90828cda0330500e700740eecb4306023b0 6cc57bb8-8891-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=215328 Fakulteta za farmacijo 0 0 0