20.500.12556/RUL-171713 Zaznavanja kvoruma pri bakterijah Pseudomonas aeruginosa Quorum sensing in Pseudomonas aeruginosa Zaznavanje kvoruma je mehanizem, ki ga bakterije uporabljajo za medcelično komunikacijo ter posledično nadzor izražanjea genov, kar jim omogoča, da delujejo enotno in ne kot posamezni mikroorganizmi. Bakterije v okolje sproščajo signalne molekule, ki se v izvenceličnem prostoru kopičijo in ob dosegu mejne koncentracije vračajo nazaj v bakterijske celice, v katerih sprožijo prepisovanje številnih genov. Več celic v okolici omogoči prisotnost signalnih molekul, kar sproži sistem zaznavanja kvoruma. Bakterije Pseudomonas aeruginosa so gram negativne bakterije, ki uporabljajo tri glavne sisteme signalizacije, to so sistemi Las, Rhl in PQS. Vsaka od njih ima svojo skupino kemijskih signalnih molekul, ki sprožijo različna zaporedja reakcij. Te omogočajo prepisovanje genov proteinov, potrebnih za nastanek biofilma, pritrjanje bakterij na tkivo gostitelja, odpornost proti antibiotikom ter sproščanje virulentnih dejavnjikov. Zaznavanje kvoruma pri bakterijah P. aeruginosa je zelo kompleksen, dinamičen in okoljsko pogojen mehanizem, ki bakterijam omogoča komunikacijo ter s tem prilagodljivost v različnih okoljih. Quorum sensing is a mechanism that bacteria use for intercellular communication and subsequent gene expression, which allows them to act as a single unit rather than individual microorganisms. Bacteria release signaling molecules into the environment, which accumulate in the extracellular space and return to bacterial cells when they reach a certain concentration, triggering the transcription of numerous genes. More cells in the vicinity enable the presence of more signaling molecules, which triggers the quorum sensing system. Bacteria Pseudomonas aeruginosa are gram-negative bacteria that use three main signaling pathways, which are systems Las, Rhl, and PQS. Each of them has its own group of chemical signaling molecules that trigger different sequences of reactions that enable the transcription of genes for proteins necessary for biofilm formation, bacterial attachment to host tissue, antibiotic resistance, and the release of virulence factors. Quorum sensing in P. aeruginosa is a very complex, dynamic, and environmentally dependent mechanism that enables bacteria to communicate and adapt to different environments. Zaznavanje kvoruma Pseudomonas aeruginosa sistem Las sistem Rhl sistem PQS biofilm inhibicija zaznavanja kvoruma Quorum sensing Pseudomonas aeruginosa system Las system Rhl system PQS biofilm inhibition of quorum sensing true false false Slovenski jezik Angleški jezik Diplomsko delo/naloga 2025-08-31 07:17:07 2025-08-31 07:17:10 2025-09-17 03:49:41 0000-00-00 00:00:00 2025 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 261891 247515651 50818.pdf 50818.pdf 1 01155404BB9F76A9A37AAEE466943DB7 a38a4651334c9ba789c643fb933582689ec00978c42e55da672f4ffdf39683de 9ab55999-8629-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=215095 Biotehniška fakulteta 0 0 0