20.500.12556/RUL-171408 Relationship between oxidative stress and cardiovascular risk in adolescents in Montenegro The pathophysiological mechanism linking oxidative stress and cardiovascular disease (CVD) is not completely elucidated, especially in young individuals. This study aimed to examine redox status in an adolescent Montenegrin population in relation to cardiovascular risk score (CVRS). A cohort of 182 adolescents (76% girls) aged between 16 and 19 was examined. Total antioxidant status (TAS), superoxide dismutase (SOD), advanced oxidation protein products (AOPPs), malondialdehyde (MDA), and total oxidant status (TOS) were determined. Pro-oxy score, anti-oxy score, and oxy score were calculated as comprehensive parameters of overall redox homeostasis status. CVRS was calculated by summarizing several risk factors (i.e., sex, age, obesity, hypertension, dyslipidemia, impaired fasting glucose, and smoking). A significant positive correlation between CVRS and TOS (rho = 0.246, p = 0.001) and AOPP (rho = 0.231, p = 0.002) and MDA (rho = 0.339, p < 0.001), respectively, and a negative correlation with the TAS/TOS ratio (rho= −0.208, p = 0.005) was observed. An increase in pro-oxy scores as well as oxy scores with CVRS risk increase were observed. Anti-oxy scores did not differ between CVRS subgroups. There is a significant relationship between cardiovascular risk score and oxidative stress in the adolescent Montenegrin population. These findings support the possibility for improvement of age-specific CVD risk algorithms by adding redox homeostasis parameters in addition to conventional ones. in silico analyses omics MSC human bone tissue gene expression gene knockdown in silico analize omika mezenhimske matične celice (MSC) izražanje genov v človeškem kostnem tkivu genska terapija osteoporoza true false true Angleški jezik Slovenski jezik Članek v reviji 2025-08-26 07:24:32 2025-08-26 07:24:37 2025-09-01 03:40:04 0000-00-00 00:00:00 2025 0 0 12 str. iss. 15, art. 7760 Vol. 26 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 602.64:616.71-007.234 1422-0067 10.3390/ijms26157650 245735171 ijms-26-07650.pdf ijms-26-07650.pdf 1 C8AF7D8F5FCD3A811943A956E410BA51 6a3d92aa63439701f223007a8c021a233a3f7dd01047509cc92f4523d43b97ef cde3be73-823e-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=214719 https://www.mdpi.com/1422-0067/26/15/7650 1 d617a089-823c-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=214718 Fakulteta za farmacijo 0 0 0