20.500.12556/RUL-171401 OSMI-4-based PROTACs do not influence O-GlcNAc transferase and O-GlcNAcylation levels in cells The O-GlcNAc transferase (OGT) inhibitors disclosed thus far are burdened with certain shortcomings. We have incorporated OSMI-4, a nanomolar OGT inhibitor, into PROTACs. The prepared chimeras failed to induce effective OGT degradation or influence O-GlcNAcylation levels in MM.1S cells. zaviralci O-GlcNAc transferaze OSMI-4 nanomolarni zaviralec OGT farmacevtska kemija true false true Angleški jezik Slovenski jezik Članek v reviji 2025-08-25 13:16:26 2025-08-25 13:16:27 2025-09-01 03:38:47 0000-00-00 00:00:00 2025 0 0 Str. 25717–25723 no. 31 Vol. 15 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 615.4:54 2046-2069 10.1039/D5RA02801A 243315203 d5ra02801a.pdf d5ra02801a.pdf 1 DF26BE48358D0CD18DBC9CA2AE200DE2 5eb22adeb28c889c8bb6b6643aa68fcf51f45b3b5cd9d7bc9b98a8b9ec20b5d4 33cdee06-81a7-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=214708 https://pubs.rsc.org/en/content/articlelanding/2025/ra/d5ra02801a 1 d2f0450c-81a4-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=214705 Fakulteta za farmacijo 0 0 0