20.500.12556/RUL-171060 Modeling how lamellipodia-driven cells maintain persistent migration and interact with external barriers Cell motility is fundamental to many biological processes, and cells exhibit a variety of migration patterns. Many motile cell types follow a universal law that connects their speed and persistency, a property that can originate from the intracellular transport of polarity cues due to the global actin retrograde flow. This mechanism was termed the “Universal Coupling between cell Speed and Persistency”(UCSP). Here we implement a simplified version of the UCSP mechanism in a coarse-grained “minimal-cell” model, which is composed of a three-dimensional vesicle that contains curved active proteins. This model spontaneously forms a lamellipodia-like motile cell shape, which is, however, sensitive and can depolarize into a nonmotile form due to random fluctuations or when interacting with external obstacles. The UCSP implementation introduces long-range inhibition, which stabilizes the motile phenotype. This allows our model to describe the robust polarity observed in cells and explain a large variety of cellular dynamics, such as the relation between cell speed and aspect ratio, cell-barrier scattering, and cellular oscillations in different types of geometric confinements. external barriers cell movement dynamics cell polarity zunanje ovire gibanje celice dinamika polarnost celice true false true Angleški jezik Slovenski jezik Članek v reviji 2025-07-30 13:52:41 2025-07-30 13:52:45 2025-07-31 04:10:52 0000-00-00 00:00:00 2025 0 0 Str. 013319-1-013319-13 issue 1, art. 013319 Vol. 7 Mar.-May 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 577 2643-1564 10.1103/PhysRevResearch.7.013319 230871555 PhysRevResearch.7.013319.pdf PhysRevResearch.7.013319.pdf 1 83AFEF4E7A939D0433CEF73700072971 882a6cb427e62cf6bc7f230b72632ed1c9101360f78057d29149e5c7e66dc20c 1e175ef6-6d3c-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=213790 https://journals.aps.org/prresearch/abstract/10.1103/PhysRevResearch.7.013319 1 aa513583-6d3b-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=213789 Fakulteta za elektrotehniko 0 0 0