20.500.12556/RUL-170318 Towards a multi-omics understanding of anaphylaxis insights into pathogenesis and biomarker identification Anaphylaxis is a severe, life-threatening hypersensitivity reaction that presents significant challenges in both clinical practice and scientific research. While individual omics studies have provided valuable insights into the genetic predisposition, immune dysregulation, and metabolic alterations associated with anaphylaxis, a comprehensive understanding of its full pathophysiology remains elusive. Multi-omics integration, which combines genomics, epigenomics, transcriptomics, proteomics, and metabolomics, has the potential to uncover novel mechanisms, biomarkers, and therapeutic targets. However, studies employing comprehensive multi-omics approaches in anaphylaxis are still limited. This review of 107 studies published between 2000 and 2024—including genomics (43), metagenomics (2), epigenomics (2), transcriptomics (20), proteomics (26), and metabolomics (14)—synthesizes findings from existing single-omics studies on human anaphylaxis, identifies key interconnections across omics layers, and underscores the critical need for large-scale, integrative research. Advancing this type of research is essential to advance our understanding of anaphylaxis, improve risk prediction, and enhance both diagnosis and treatment strategies. anaphylaxis multi-omics pathophysiology biomarker precision medicine anafilaksija patogeneza biomarkerji omike imunologija true false true Angleški jezik Slovenski jezik Članek v reviji 2025-07-03 13:53:46 2025-07-03 13:53:47 2026-06-09 04:11:40 0000-00-00 00:00:00 2025 0 0 Objavljen je popravek tega članka (gl. datoteko Priloga – Erratum): Clinical reviews in allergy & immunology, 2025, Vol. 68, iss. 1, art. 78, DOI: https://doi.org/10.1007/s12016-025-09091-w. 18 str. iss. 1, art. 61 Vol. 68 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 577.27 1080-0549 10.1007/s12016-025-09069-8 241003267 RAZ_Svetina_Manca_2025.pdf RAZ_Svetina_Manca_2025.pdf 1 012632763745E9FBB65A43372E093CAC 61633977260ee23e749bf5e5e9312d77aa8df64ea633eb26e4667dda07ab50f3 05ad14bb-ead5-11f0-bf92-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=225010 s12016-025-09091-w.pdf s12016-025-09091-w.pdf Erratum Erratum 1 F1BB2D883046DF197080B052780F9927 1267a713ddd9cb3f852cc3d8532f25c654ebfe5369ac7eee667b467d91682c85 db218220-6330-11f1-9b0d-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=235100 https://link.springer.com/article/10.1007/s12016-025-09069-8 0 20a49804-ead5-11f0-bf92-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=225011 Biotehniška fakulteta Fakulteta za farmacijo 0 0 0