20.500.12556/RUL-169964 Sustainable synthetic routes to deuterium-labelled organic compounds using immobilized and recyclable (bio)catalysts Deuterium(D)-labelled organic compounds are used in many applications e.g., as therapeutic agents, internal standards in drug discovery and development, and new functional materials including dyes, catalysts, and light emitters. Conventionally, the synthesis of D-labelled compounds relies on (bio)catalysts due to their regio- and stereoselectivity, mild reaction conditions, and treatment of a broad scope of substrates. However, most (bio)catalysts are expensive to prepare/isolate, and some contain precious metals (PMs), e.g., Ir, Pd, whose markets are unpredictable, and which need to be separated from the products at great expense, post-reaction. With the general shift away from traditional ‘make-use-dispose’ approaches to ones that are less wasteful, the use of recyclable catalysts in both batch and continuous flow systems are increasingly employed. In this work, we comprehensively and critically review the catalysts and immobilization and recycling strategies implemented for the preparation of D-labelled organic compounds. Our aim is to highlight the most effective advances and expose the gaps in the literature to inform future research. immobilized recyclable deuterated deuterogenation deuteration deuterodehalogenation deuterodecarboxylation imobiliziran recikliranje deuteriran deuterogenacija deuteracija deuterodehalogenacija deuterodekarboksilacija true false true Angleški jezik Slovenski jezik Članek v reviji 2025-06-27 08:29:24 2025-06-27 08:29:26 2025-06-28 04:07:59 0000-00-00 00:00:00 2025 0 0 35 str. iss. 1 Vol. 6 Feb. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 547.1 2666-5549 10.1016/j.gresc.2024.09.008 210275331 RAZ_Jedlovcnik_Luka_2025.pdf RAZ_Jedlovcnik_Luka_2025.pdf 1 490329CCB7CC2D212EF99689BC3F3B97 f520f9f620bcf13228c2a4bbedc49d8e992b3331fadf2abbacff9d010e4db72a a22dd1fa-531e-11f0-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=211818 https://www.sciencedirect.com/science/article/pii/S2666554924001029 1 32cf2ba2-531e-11f0-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=211817 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0