20.500.12556/RUL-169411 Vpliv omejitve pretoka krvi v skeletnih mišicah na mikrožilne odzive v koži med aerobno vadbo pri zdravih mladih moških magistrsko delo Effects of aerobic exercises with blood flow restriction on the microvasculature in healthy young men master thesis Uvod: Koža je največji organ človeškega telesa, ki ima ključno vlogo pri uravnavanju telesne temperature, zaščiti telesa pred zunanjimi vplivi in zaznavanju dražljajev. Kožo v grobem delimo na poraščeno in neporaščeno (akralno). Glavna naloga kožnega mikrožilja je prehranska mikrocirkulacija, izločanje toplote in prilagoditve na različne presnovne ter termoregulacijske zahteve telesa. Med vadbo se funkcija mikrožilja prilagodi povečanemu metabolizmu. Vadba z omejenim pretokom krvi v aktivne skeletne mišice (ishemična vadba) je v preteklih raziskavah pokazala večji krvni pretok, izboljšanje oksigenacije in reaktivno hiperemijo po koncu okluzije. Kljub temu pa so njeni učinki na kožno mikrocirkulacijo še premalo raziskani. Namen: Namen raziskave je bil ugotoviti vpliv ishemične aerobne vadbe na mikrožilne odzive pri zdravih mladih moških. Metode dela: Preiskovanci (n = 21) so opravili tri meritve na sobnem kolesu. Na prvih meritvah smo naredili submaksimalno obremenitveno testiranje in določili V˙O2maks. Pri naslednjih testiranjih so preiskovanci kolesarili pri 40 % in 60 % V˙O2maks z omejenim krvnim pretokom v aktivne skeletne mišice ali brez. Med vadbo in 15-minutnim okrevanjem po njej smo merili arterijski krvni tlak, krvni pretok kože, temperaturo kože in transkutani parcialni tlak kisika pod okluzijo, na podlakti in blazinici prsta. Rezultati: Ugotovili smo statistično značilno večji krvni pretok in kožno žilno prevodnost na poraščenih delih kože pri ishemični vadbi v primerjavi s kontrolo (p < 0,05), tako med vadbo kot v fazi okrevanja. Prav tako smo ugotovili razlike v prekrvavljenosti akralne kože, ki je bila statistično značilno manjša pri ishemični vadbi, v okrevanju pa je krvni pretok potreboval dalj časa za vzpostavitev mirovnih vrednosti. Med ishemično vadbo je bil viden trend razlike v višji metabolični obremenitvi in aktivaciji simpatikusa, kar se odraža v povečanem srednjem arterijskem tlaku, ki pa ni bil statistično značilno večji. Po sprostitvi okluzije smo ugotovili reaktivno hiperemijo kože (p < 0,05) na spodnjem udu. Razprava in zaključek: Aerobna vadba z omejenim krvnim pretokom v aktivne skeletne mišice pri zdravih mladih preiskovancih predstavlja varno in učinkovito metodo za izboljšanje kožne mirkocirkulacije, endotelijske funkcije in oksigenacije tkiva. Opazovani učinki bi bili lahko uporabni pri rehabilitaciji bolnikov s periferno arterijsko boleznijo in slabim celjenjem ran. Introduction: The skin is the largest organ of the human body, playing a crucial role in thermoregulation, protecting the body from external influences, and sensory perception. The skin can broadly be divided into hairy (non-glabrous) and non-hairy (acral or glabrous) regions. The primary function of the skin microvasculature includes nutritional microcirculation, heat dissipation, and adaptation to various metabolic and thermoregulatory demands of the body. During physical activity, the function of the microvasculature adapts to increased metabolism. Previous studies on blood flow restriction training have demonstrated increased blood flow, improved oxygenation, and reactive hyperemia following the release of occlusion. However, its effects on skin microcirculation remain underexplored. Purpose: The aim of this study was to investigate the effects of aerobic ischemic exercise on the cardiovascular system, with an emphasis on microvasculature in healthy young men. Methods: The participants (n = 21) underwent three tests on a cycle ergometer. In the first session, a submaximal exercise test was conducted to determine V̇O2maks. In subsequent tests, participants cycled at 40% and 60% of V̇O2max with or without restricted blood flow to the active skeletal muscles. Physiological responses were also monitored during the recovery phase. Measurements included arterial blood pressure, skin blood flow, skin temperature, and transcutaneous partial oxygen pressure (tcpO₂) under occlusion, on the forearm, and on the fingertip. Results: Statistically significant increases in skin blood flow and cutaneous vascular conductance were observed in the hairy regions of the skin during ischemic exercise compared to the control condition (p < 0.05), both during exercise and recovery. Differences were also found in the perfusion of acral skin, which was significantly lower during BFR exercise. Additionally, the recovery of blood flow to resting values in acral skin took longer. Ischemic exercise was associated with higher metabolic stress and sympathetic activation, reflected in an increased mean arterial pressure, although the increase was not statistically significant. Reactive hyperemia (p < 0.05) was observed in the lower limb following the release of occlusion Discussion and conclusion: Aerobic exercise with restricted blood flow to active skeletal muscles in healthy young participants represents a safe and effective method for improving skin microcirculation, endothelial function, and tissue oxygenation. This method has potential applications in the rehabilitation of patients with peripheral arterial disease and impaired wound healing. magistrska dela fizioterapija aerobna vadba kožna mikrocirkulacija vadba z omejenim krvnim pretokom v aktivne skeletne mišice ishemična vadba poraščena in neporaščena koža master's theses physiotherapy aerobic exercise skin microcirculation blood flow restriction exercise ischemic exercise hairy and non-hairy skin true false false [J. Sinožić] Slovenski jezik Angleški jezik Magistrsko delo/naloga 2025-05-28 07:45:35 2025-05-28 07:45:47 2025-05-29 04:38:53 0000-00-00 00:00:00 2025 0 Ljubljana 0 Ljubljana 48 str., [11] str. pril. 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 615.8 146233 237426179 49816.pdf 49816.pdf 1 7E464CAF7836220EFDAEE4BB3EA2EDD9 96cb1436d62470c1af8c3b53ae72c88ed8efed6fab7a51e725a561a075e6f45c b6c2d05f-3b85-11f0-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=210743 Zdravstvena fakulteta 0 0 0