20.500.12556/RUL-169397 Clinical properties and non-clinical testing of mineralocorticoid receptor antagonists in in vitro cell models Mineralocorticoid receptor antagonists (MRAs) are one of the renin–angiotensin–aldosterone system inhibitors widely used in clinical practice. While spironolactone and eplerenone have a long-standing profile in clinical medicine, finerenone is a novel agent within the MRA class. It has a higher specificity for mineralocorticoid receptors, eliciting less pronounced adverse effects. Although approved for clinical use in patients with chronic kidney disease and heart failure, intensive non-clinical research aims to further elucidate its mechanism of action, including dose-related selectivity. Within the field, animal models remain the gold standard for non-clinical testing of drug pharmacological and toxicological properties. Their role, however, has been challenged by recent advances in in vitro models, mainly through sophisticated analytical tools and developments in data analysis. Currently, in vitro models are gaining momentum as possible platforms for advanced pharmacological and pathophysiological studies. This article focuses on past, current, and possibly future in vitro cell models research with clinically relevant MRAs. finerenone mineralocorticoids spironolactone eplerenone in vitro techniques mineralocorticoid receptor antagonists true false true Angleški jezik Ni določen Članek v reviji 2025-05-27 14:56:20 2025-05-27 14:56:21 2025-05-28 04:11:59 0000-00-00 00:00:00 2024 0 0 21 str. iss. 16, art. 9088 Vol. 25 2024 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 616.6 1422-0067 10.3390/ijms25169088 205135619 ijms-25-09088-v2.pdf ijms-25-09088-v2.pdf 1 83961C021D1C6245FC8003987426235D e151b5251cc2cab8a97a333684e99df33eb9237ab52220b084b50b3337151f45 21990eb3-3af9-11f0-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=210722 https://www.mdpi.com/1422-0067/25/16/9088 1 b21501e1-3af8-11f0-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=210720 Medicinska fakulteta 0 0 0