20.500.12556/RUL-169395 Design optimisation of a flat-panel, limited-angle TOF-PET scanner a simulation study In time-of-flight positron emission tomography (TOF-PET), a coincidence time resolution (CTR) below 100 ps reduces the angular coverage requirements and, thus, the geometric constraints of the scanner design. Among other possibilities, this opens the possibility of using flat-panel PET detectors. Such a design would be more cost-accessible and compact and allow for a higher degree of modularity than a conventional ring scanner. However, achieving adequate CTR is a considerable challenge and requires improvements at every level of detection. Based on recent results in the ongoing development of optimised TOF-PET photodetectors and electronics, we expect that within a few years, a CTR of about 75 ps will be achievable at the system level. In this work, flat-panel scanners with four panels and various design parameters were simulated, assessed and compared to a reference scanner based on the Siemens Biograph Vision using NEMA NU 2-2018 metrics. Point sources were also simulated, and a method for evaluating spatial resolution that is more appropriate for flat-panel geometry is presented. We also studied the effects of crystal readout strategies, comparing single-crystal and module readout levels. The results demonstrate that with a CTR below 100 ps, a flat-panel scanner can achieve image quality comparable to that of a reference clinical scanner, with considerable savings in scintillator material. PET detector development time-of-flight time-of-flight positron emission tomography TOF-PET GATE Monte Carlo simulation CASToR pozitronska emisijska tomografija razvoj tomografov čas preleta tomografija metoda Monte Carlo true false true Angleški jezik Slovenski jezik Članek v reviji 2025-05-27 12:38:17 2025-05-27 12:38:23 2025-05-28 04:11:59 0000-00-00 00:00:00 2024 0 0 15 str. iss. 17, art. 1976 Vol. 14 Sep. 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 539.1 2075-4418 10.3390/diagnostics14171976 207781123 diagnostics-14-01976-v2.pdf diagnostics-14-01976-v2.pdf 1 E16B3C809188DC4BC06E100972B3C284 98dd187292b06827eaa9b556a52b2a3be207041375f803b26be3aada87e10de0 f9aad34a-3ae5-11f0-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=210716 https://www.mdpi.com/2075-4418/14/17/1976 1 6f40fa66-3ae5-11f0-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=210715 Fakulteta za matematiko in fiziko 0 0 0