20.500.12556/RUL-166829 Genetic predisposition of suicidal behavior variants in GRIN2B, GABRG2, and ODC1 genes in attempted and completed suicide in two Balkan populations Completed suicide accounts for over 700,000 deaths worldwide annually, while attempted suicide is 20 times more frequent. Genetic background is an important factor contributing to suicidal behavior, including candidate genes in glutamate, γ-aminobutyric acid (GABA), and polyamine systems. Our aim was to differentiate genetic predispositions underlying different types of suicidal behavior, attempted and completed suicide, in two Balkan populations. Analysis of variants in the genes GRIN2B (rs2268115 and rs220557), GABRG2 (rs424740), and ODC1 (rs1049500 and rs2302614) was performed on a study sample including 173 suicide attempters with comorbid psychiatric disorders, 216 non-suicidal psychiatric patients and 172 healthy controls from Serbia, and 333 suicide completers and 356 non-suicidal autopsy controls from Slovenia. CA genotype of rs220557 in GRIN2B gene increased the risk for completed suicide (P = 0.021), and violent suicide (P = 0.037), compared to controls. In ODC1 gene, CA genotype of rs2302614 decreased the risk for completed suicide compared to suicide attempt (P = 0.012). Marginally, AC haplotype for variants rs1049500-rs2302614 in ODC1 gene decreased the risk for completed suicide compared to suicide attempt (P = 0.052). Specific genetic variants of glutamate and polyamine systems are differently distributed among diverse suicidal phenotypes, providing further information on the implication of these systems in suicidality. associations genetic variant single nucleotide polymorphism suicidal behavior združenja genetska različica enojni nukleotidni polimorfizem samomorilno vedenje true false true Angleški jezik Slovenski jezik Članek v reviji 2025-01-27 11:17:06 2025-01-27 11:17:10 2025-06-11 04:28:58 0000-00-00 00:00:00 2025 0 0 Str. 1221–1230 iss. 4 Vol. 275 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.89 1433-8491 10.1007/s00406-024-01895-9 209197571 s00406-024-01895-9_(1).pdf s00406-024-01895-9_(1).pdf 1 B2E53B7CBDDE0292419E50D0698C1FC5 806cc8a59cc14a50d6c637d1d5a41891a2a2d03ccaf28605f280fe9d3b8e42c3 7dbde72f-45d1-11f0-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=211465 https://link.springer.com/article/10.1007/s00406-024-01895-9 1 10115177-dc97-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=198756 Medicinska fakulteta 0 0 0