20.500.12556/RUL-166482 Steroid sulfatase and sulfotransferases in the estrogen and androgen action of gynecological cancers current status and perspectives Sulfatase (STS) and sulfotransferases (SULT) have important role in the biosynthesis and action of steroid hormones. STS catalyzes the hydrolysis of estrone-sulfate (E1-S) and dehydroepiandrosterone-sulfate (DHEA-S), while sulfotransferases catalyze the reverse reaction and require 3-phosphoadenosine-5-phosphosulfate as a sulfate donor. These enzymes control the concentration of active estrogens and androgens in peripheral tissues. Aberant expression of STS and SULT genes has been found in both, benign hormone-dependent diseases and hormone-dependent cancers. The aim of this review is to present the current knowledge on the role of STS and SULT in gynecological cancers, endometrial (EC) and ovarian cancer (OC). EC is the most common and OC the most lethal gynecological cancer. These cancers primarily affect postmenopausal women and therefore rely on the local production of steroid hormones from inactive precursors, either DHEA-S or E1-S. Following cellular uptake by organic anion transporting polypeptides (OATP) or organic anion transporters (OAT), STS and SULT regulate the formation of active estrogens and androgens, thus disturbed balance between STS and SULT can contribute to the onset and progression of cancer. The importance of these enzymes in peripheral estrogen biosynthesis has long been recognized, and this review provides new data on the important role of STS and SULT in the formation and action of androgens, their regulation and inhibition, and their potential as prognostic biomarkers. androgens estrogens intracrinology sulfatase sulfotransferase androgeni estrogeni intrakrinologija sulfataza sulfotransferaza true false true Angleški jezik Slovenski jezik Članek v reviji 2025-01-14 14:15:10 2025-01-14 14:15:16 2025-01-20 13:21:48 0000-00-00 00:00:00 2024 0 0 Str. 411–422 iss. 4 Vol. 68 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 61:577.2 0071-1365 10.1042/EBC20230096 202276355 ebc-2023-0096c.pdf ebc-2023-0096c.pdf 1 4BB339301CE1A1F9D6C2231150C1FD0D d1df5cc23fd196193bc64dddc9110eaa8d3db061011161fff693afe0e77df721 726a78ce-d279-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=198131 https://portlandpress.com/essaysbiochem/article/doi/10.1042/EBC20230096/234699/Steroid-sulfatase-and-sulfotransferases-in-the 1 d9f14453-d278-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=198130 Medicinska fakulteta 0 0 0