20.500.12556/RUL-166312 Management of patients with venous thromboembolism and a high recurrence risk estimated by the Vienna Prediction Model: a prospective cohort study Background: The Vienna Prediction Model (VPM) identifies patients with a first unprovoked deep vein thrombosis of the leg and/or pulmonary embolism who have a low recurrence risk and may, therefore, not benefit from extended-phase anticoagulation. Objectives: The aim of this study was to evaluate patients with a predicted high risk of recurrent venous thromboembolism (VTE). Methods and Results: We prospectively followed 266 patients in whom the VPM had predicted a recurrence risk of more than 5.5% at 1 year for a median of 13.5 months. Their median age was 56 years, and 96% were men. After the VPM risk assessment, 196 patients restarted anticoagulation. While on anticoagulation, none of the patients experienced recurrent VTE, whereas 4 patients had nonmajor clinically relevant bleeding (absolute bleeding rate, 1.8 [95% CI, 0.5-4.5] events per 100 patient-years). Seventy patients were left untreated after VPM risk assessment for various reasons. Among patients not using anticoagulation, 15 had recurrence (absolute recurrence rate, 18.1 [95% CI, 10.1, 29.9] events per 100 person-years). According to the extended Kaplan–Meier analysis, the probability of VTE recurrence in patients not on anticoagulation was 10.1% and 17.9% at 6 and 12 months after VPM risk assessment, respectively. Conclusion: Anticoagulant therapy is effective and safe in patients with an unprovoked VTE, in whom the VPM had predicted a high risk of recurrent VTE. If these patients are left untreated, the risk of recurrence is high. deep vein thrombosis pulmonary embolism venous thromboembolism Vienna Prediction Model recurrence globoka venska tromboza pljučna embolija venska trombembolija true false true Angleški jezik Slovenski jezik Članek v reviji 2025-01-07 11:12:32 2025-01-07 11:12:36 2025-01-08 04:00:00 0000-00-00 00:00:00 2025 0 0 6 str. iss. 1, art. 102649 Vol. 9 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.1 2475-0379 10.1016/j.rpth.2024.102649 221026307 Management_of_patients_with_venous_thro...pdf Management_of_patients_with_venous_thro...pdf 1 76DB48AB5F9C762A2C0E56D96BE61FA8 5fa1f644585f43cb8c8e81f24d56c326e37265edb3d57ba0ad6a9ed81149ba48 7491d33b-ccdf-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=197839 https://www.sciencedirect.com/science/article/pii/S2475037924003443 1 363fa36e-ccdf-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=197838 Biotehniška fakulteta 0 0 0