20.500.12556/RUL-166309 Organi na čipu in njihov potencial pri vrednotenju nanodostavnih sistemov Organs-on-a-chip and their potential in characterization of nanodelivery systemses Napredek farmacevtske nanotehnologije spremlja potreba po vrednotenju razvitih nanodostavnih sistemov in nanozdravil na modelih, ki posnemajo pogoje in vivo. To omogočajo organi na čipu, ki temeljijo na gojenju različnih vrst celic v tridimenzionalnem ogrodju v pretočnem sistemu. Prednost te tehnologije je možnost gojenja celic v bolj biorelevantnem okolju, kot so pogoji v klasičnih statičnih dvodimenzionalnih celičnih kulturah, in sicer v prisotnosti biomehanskih sil, ki delujejo na celice v čipih, kar vodi v spremenjeno izražanje genov in spremenjen fenotip celic. Organi na čipu se v raziskavah največ uporabljajo z namenom postavljanja modelov bolezni in za vrednotenje zdravilnih učinkovin in vitro. Z razvojem tehnologije se njihova uporaba širi tudi na vrednotenje nanodostavnih sistemov in nanozdravil, predvsem za vrednotenje njihovega prehajanja skozi biološke bariere ter proučevanje njihovega protitumornega delovanja in vitro. Z nadaljnjim razvojem lahko pričakujemo prenos tehnologije organov na čipu iz raziskovalnih laboratorijev v širšo uporabo v farmacevtski industriji. The advancement of pharmaceutical nanotechnology is accompanied by the need to evaluate nanodelivery systems, especially nanoparticles, on models that mimic in vivo conditions. This is enabled by organs-on-a-chip, which represent cells cultured in a three-dimensional extracellular matrix with relevant fluidics. This setup offers a more biorelevant environment than traditional two-dimensional static cell cultures due to the biomechanical forces that influence gene expression and cell phenotype. Most research in the field is focused on establishing complex disease models or in vitro drug evaluation. Moreover, their use is expanding to include the evaluation of nanodelivery systems and nanomedicines. These chips are primarily used to study nanoparticle transport across biological barriers and the efficacy of nanodelivery systems against tumors in vitro. Continued development is expected to expand the use of organs-on-a-chip from primarily research labs to broader applications within the pharmaceutical industry. nanodelci organ na čipu tumor na čipu vrednotenje in vitro dostavni sistemi drug delivery systems nanoparticles organ-on-achip tumor-on-a-chip in vitro characterisation true false true Slovenski jezik Angleški jezik Članek v reviji 2025-01-07 10:54:34 2025-01-07 10:54:42 2025-01-08 03:59:59 0000-00-00 00:00:00 2024 0 0 Str. 357-366 št. 5 Letn. 75 2024 0000-00-00 Zaloznikova NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 615.015.14 0014-8229 220980739 kirbu-kocbek.pdf kirbu-kocbek.pdf 1 939B2A9E39426D826DD7CF32BFE4E844 94b6abe07f5194031a9f37d73e9e22ed3bddc6a9928f0244de94460c013084cd 23f9878a-ccdd-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=197832 https://www.sfd.si/wp-content/uploads/2024/12/kirbu-kocbek.pdf 0 543b6305-ccdd-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=197834 Fakulteta za farmacijo 0 0 0