20.500.12556/RUL-166166 Primerjava postopkov in rezultatov ravnotežne dialize in difuzije skozi umetne lipidne membrane pri določanju vezave učinkovin na proteine krvne plazme Comparison of procedures and results of equilibrium dialysis and diffusion through artificial lipid membranes for the determination of drug binding to blood plasma proteins Cilj naloge je bil ugotoviti, kakšne so prednosti in slabosti metode PAMPA pri določanju vezave učinkovin na plazemske proteine v primerjavi z ravnotežno dializo, ki velja za zlati standard. Primerjavo v postopkih in rezultatih obeh metod smo izvedli na 12 modelnih učinkovinah z raznoliko in znano vezavo na proteine ter s petimi spojinami iz razvoja novih učinkovin s Katedre za farmacevtsko kemijo. The aim of this thesis was to determine the advantages and disadvantages of the PAMPA method in determining the binding of active ingredients to plasma proteins compared to equilibrium dialysis, which is considered the gold standard. Comparisons in procedures and results of both methods were performed on 12 model active ingredients with diverse and known protein binding and on five compounds from the development of new active ingredients from the Department of Pharmaceutical Chemistry. ravnotežna dializa PAMPA albumin določanje vezave equilibrium dialysis PAMPA albumin binding determination true false false Slovenski jezik Angleški jezik Magistrsko delo/naloga 2024-12-22 07:45:06 2024-12-22 07:45:10 2024-12-23 03:57:53 0000-00-00 00:00:00 2024 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 2025-12-20 114502 26786.pdf 26786.pdf 1 AF5D6E3160D3BA55C4166CDAA6362284 0e55f875420b7323e567660d62c0da3ea7be968b7b83812348170c5cd7b1615c b2189753-c02f-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=197570 Fakulteta za farmacijo 0 0 0