20.500.12556/RUL-166034 Context-specific genome-scale metabolic modelling and its application to the analysis of COVID-19 metabolic signatures Genome-scale metabolic models (GEMs) have found numerous applications in different domains, ranging from biotechnology to systems medicine. Herein, we overview the most popular algorithms for the automated reconstruction of context-specific GEMs using high-throughput experimental data. Moreover, we describe different datasets applied in the process, and protocols that can be used to further automate the model reconstruction and validation. Finally, we describe recent COVID-19 applications of context-specific GEMs, focusing on the analysis of metabolic implications, identification of biomarkers and potential drug targets. context-specific genome scale metabolic modelling constraint-based modelling omics data integration model extraction method COVID-19 computational pipeline metabolic fluxes context-specific model kontekstno specifično modeliranje metabolizma modeliranje z omejitvami integracija omskih podatkov metode za ekstrakcijo modelov COVID-19 true false true Angleški jezik Slovenski jezik Članek v reviji 2024-12-18 11:55:38 2024-12-18 11:55:39 2025-11-10 10:39:35 0000-00-00 00:00:00 2023 0 0 28 str. iss. 1, art. 126 Vol. 13 Jan. 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 004:578.834 2218-1989 10.3390/metabo13010126 137763843 RAZ_Moskon_Miha_2023.pdf RAZ_Moskon_Miha_2023.pdf 1 AA1E8D3D5D14B5AA870C38F707191F21 f8619811d51208e132ce24fe550601997f2b0e546e435dad5e0523dc8d1b8c98 a3778606-bd2f-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=197405 https://www.mdpi.com/2218-1989/13/1/126 1 1ec48892-bd2f-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=197404 Fakulteta za računalništvo in informatiko Medicinska fakulteta 0 0 0