20.500.12556/RUL-165922 The outcome of metabolic and bariatric surgery in morbidly obese patients with different genetic variants associated with obesity a systematic review Metabolic and bariatric surgery (MBS) effectively treats obesity and related comorbidities, though individual responses vary. This systematic review examines how genetic variants influence MBS outcomes in morbidly obese patients. A comprehensive search in PubMed, Embase, Medline, and the Cochrane Library identified 1572 studies, with 52 meeting the inclusion criteria. Two reviewers independently filtered and selected studies, including relevant cross-references. Research focused on polymorphisms in genes such as UCP2, UCP3, 5-HT2C, MC4R, FKBP5, FTO, CAT haplotypes, LYPAL-1, PTEN, FABP-2, CNR1, LEP656, LEP223, GLP-1R, APOA-1, APOE, ADIPOQ, IL-6, PGC1a, TM6SF2, MBOAT7, PNPLA3, TCF7L2, ESR1, GHSR, GHRL, CD40L, DIO2, ACSL5, CG, TAS2R38, CD36, OBPIIa, NPY, BDNF, CLOCK, and CAMKK2. Most studies explored associations with post-surgery weight loss, while some examined metabolic, cardiovascular, taste, and eating behavior effects as well. Understanding the role of genetic factors in weight loss and metabolic outcomes post-MBS can help tailor personalized treatment plans for improved efficacy and long-term success. Further research with larger sample sizes and extended follow-up is needed to clarify the effects of many genetic variants on MBS outcomes in morbidly obese patients. obesity morbid obesity metabolic and bariatric surgery genetic variant polymorphism single nucleotide polymorphism debelost morbidna debelost presnovna in bariatrična kirurgija genetska različica polimorfizem enojni nukleotidni polimorfizem true false true Angleški jezik Slovenski jezik Članek v reviji 2024-12-13 10:14:38 2024-12-13 10:14:43 2025-11-10 11:26:32 0000-00-00 00:00:00 2024 0 0 24 str. iss. 15, art. 2510 Vol. 16 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-07 2072-6643 10.3390/nu16152510 203541763 RAZ_Zafirovska_Marija_2024.pdf RAZ_Zafirovska_Marija_2024.pdf 1 3F78D2B9B07942C74FB25D1599590270 126fd6099520c94bfffe296260201f0bf6ba8bb45817fd2b6cb9ba553dab244e cccda64d-b932-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=197208 https://www.mdpi.com/2072-6643/16/15/2510 1 2e19d320-b932-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=197201 Medicinska fakulteta 0 0 0