20.500.12556/RUL-165244 Depressive disorder and antidepressants from an epigenetic point of view Depressive disorder is a complex, heterogeneous disease that affects approximately 280 million people worldwide. Environmental, genetic, and neurobiological factors contribute to the depressive state. Since the nervous system is susceptible to shifts in activity of epigenetic modifiers, these allow for significant plasticity and response to rapid changes in the environment. Among the most studied epigenetic modifications in depressive disorder is DNA methylation, with findings centered on the brain-derived neurotrophic factor gene, the glucocorticoid receptor gene, and the serotonin transporter gene. In order to identify biomarkers that would be useful in clinical settings, for diagnosis and for treatment response, further research on antidepressants and alterations they cause in the epigenetic landscape throughout the genome is needed. Studies on cornerstone antidepressants, such as selective serotonin reuptake inhibitors, selective serotonin and norepinephrine reuptake inhibitors, norepinephrine, and dopamine reuptake inhibitors and their effects on depressive disorder are available, but systematic conclusions on their effects are still hard to draw due to the highly heterogeneous nature of the studies. In addition, two novel drugs, ketamine and esketamine, are being investigated particularly in association with treatment of resistant depression, which is one of the hot topics of contemporary research and the field of precision psychiatry. depression epigenetics DNA methylation histone tail modification microRNA antidepressant depresija epigenetika metilacija DNA true false true Angleški jezik Slovenski jezik Članek v reviji 2024-11-28 07:36:08 2024-11-28 07:36:11 2025-11-14 04:32:59 0000-00-00 00:00:00 2022 0 0 Str. 1150-1168 iss. 9 Vol. 12 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.89 2220-3206 10.5498/wjp.v12.i9.1150 122214915 RAZ_Salamon_Arcan_Iris_2022.pdf RAZ_Salamon_Arcan_Iris_2022.pdf 1 33B2569826E5875F4FB20BE70CF368D3 abc28d592fe91296c990f1ee6e815e68228077bfde513e47593ee47b6b3a51a6 cb900e55-c086-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=221856 https://www.wjgnet.com/2220-3206/full/v12/i9/1150.htm 0 f9e7cf0e-ad53-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=196306 Medicinska fakulteta 0 0 0