20.500.12556/RUL-165217 Effects of mindfulness-based therapy on clinical symptoms and DNA methylation in patients with polycystic ovary syndrome and high metabolic risk Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder affecting women of reproductive age. Research has shown that epigenetic alterations such as DNA methylation may play a role in the development and progression of abnormal ovarian function and metabolic disorders in PCOS. Studies have identified specific genes (related with insulin signaling and steroid hormone metabolism) that are methylated in women with PCOS. DNA methylation appears to respond to various interventions aimed at altering health and lifestyle factors. We tested the efficacy of a mindfulness-based stress reduction program (MBSR) in PCOS patients. We examined its effects on anthropometric measurements, mental health and wellbeing, and alterations in DNA methylation in peripheral blood. MBSR was associated with a reduction in body mass index, waist circumference and blood glucose level, an improvement in subjectively perceived general health, emotional role limitation, and levels of pain, as well as mindfulness-like traits. MBSR reduced the expression of anxious symptomatology and subjectively perceived stress. Methylation changes were observed in four genes: COMT, FST, FKBP51, and MAOA. We conclude that MBSR may be a useful supplementary therapy to mitigate the deleterious effects of PCOS on mental health. mindfulness-based stress reduction program polycystic ovary syndrome DNA methylation epigenetics candidate genes depression anxiety program zmanjševanja stresa ki temelji na čuječnosti sindrom policističnih jajčnikov metilacija DNA epigeneza kandidatni geni depresija anksioznost true false true Angleški jezik Slovenski jezik Članek v reviji 2024-11-27 09:10:50 2024-11-27 09:10:53 2025-11-10 14:18:54 0000-00-00 00:00:00 2023 0 0 Str. 2717-2737 iss. 4 Vol. 45 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.4 1467-3045 10.3390/cimb45040178 146533635 RAZ_Dema_Hana_2023.pdf RAZ_Dema_Hana_2023.pdf 1 EF4EDE3FC5436204604C8002E4508163 a3c0377d355a18c8627d17627c9938ee23c5da7773c383041d3bc4f1f3f7d511 c43e95d4-ac97-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=196255 https://www.mdpi.com/1467-3045/45/4/178 1 b6730ac7-ac96-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=196252 Medicinska fakulteta 0 0 0