20.500.12556/RUL-165213 Epigenetics in psychiatry beyond DNA methylation The global burden of psychopathologies appears to be underestimated, since the global psychiatric disorder burden is exceeding other medical burdens. To be able to address this problem more effectively, we need to better understand the etiology of psychiatric disorders. One of the hallmarks of psychiatric disorders appears to be epigenetic dysregulation. While some epigenetic modifications (such as DNA methylation) are well known and studied, the roles of others have been investigated much less. DNA hydroxymethylation is a rarely studied epigenetic modification, which as well as being an intermediate stage in the DNA demethylation cycle is also an independent steady cell state involved in neuro- development and plasticity. In contrast to DNA methylation, DNA hydroxymethylation appears to be related to an increase in gene expression and subsequent protein expression. Although no particular gene or genetic locus can be at this point linked to changes in DNA hydroxymethylation in psychiatric disorders, the epigenetic marks present good potential for biomarker identification because the epigenetic landscape is a result of the interplay between genes and environment, which both influence the development of psychiatric disorders, and because hydroxymethylation changes are particularly enriched in the brain and in synapse-related genes. mood disorders suicide schizophrenia bipolar disorder hydroxymethylation 5-hydroxymethycytosine gene expression motnje razpoloženja samomor shizofrenija bipolarna motnja hidroksimetilacija 5-hidroksi-metil‐citozin izražanje genov true false true Angleški jezik Slovenski jezik Članek v reviji 2024-11-27 08:55:13 2024-11-27 08:55:13 2025-11-14 04:32:59 0000-00-00 00:00:00 2023 0 0 Str. 319-330 iss. 6 Vol. 13 Jun. 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.89 2220-3206 10.5498/wjp.v13.i6.319 156170755 RAZ_Kouter_Katarina_2023.pdf RAZ_Kouter_Katarina_2023.pdf 1 0EF289596B07720D22C731DD18C0BD96 8b789c793aa598fd4eb9e8afa5e9e03a7e76bd427fe1ca3e8394a544742948f4 9f0b55e3-c08a-11f0-9328-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=221858 https://www.wjgnet.com/2220-3206/full/v13/i6/319.htm 0 533ff990-ac96-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=196251 Medicinska fakulteta 0 0 0