20.500.12556/RUL-165016 Cannabinoids and triple-negative breast cancer treatment Triple-negative breast cancer (TNBC) accounts for about 10-20% of all breast cancer cases and is associated with an unfavorable prognosis. Until recently, treatment options for TNBC were limited to chemotherapy. A new successful systemic treatment is immunotherapy with immune checkpoint inhibitors, but new tumor-specific biomarkers are needed to improve patient outcomes. Cannabinoids show antitumor activity in most preclinical studies in TNBC models and do not appear to have adverse effects on chemotherapy. Clinical data are needed to evaluate efficacy and safety in humans. Importantly, the endocannabinoid system is linked to the immune system and immunosuppression. Therefore, cannabinoid receptors could be a potential biomarker for immune checkpoint inhibitor therapy or a novel mechanism to reverse resistance to immunotherapy. In this article, we provide an overview of the currently available information on how cannabinoids may influence standard therapy in TNBC. triple-negative breast cancer breast cancer cancer treatment cannabinoids endocannabinoid system chemotherapy immunotherapy immune system tumor microenvironment immune checkpoint inhibitors trojno negativni rak dojke rak dojke onkološko zdravljenje kanabinoidi true false true Angleški jezik Slovenski jezik Članek v reviji 2024-11-21 06:59:32 2024-11-21 06:59:35 2025-01-30 14:28:31 0000-00-00 00:00:00 2024 0 0 13 str. Vol. 15, art. 1386548 2024 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 618.1 1664-3224 10.3389/fimmu.2024.1386548 204044547 RAZ_Dobovisek_Luka_2024.pdf RAZ_Dobovisek_Luka_2024.pdf 1 DA666E120BC28ACBE07BF76A7E32A232 d0625561520e5e3414b66949420efc01e0290cadef07609feab1298bbc7bb0c6 bc90135d-a7cd-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=195932 https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1386548/full 1 6447a6c6-a7cd-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=195931 Medicinska fakulteta 0 0 0