20.500.12556/RUL-164947 The contribution of type 2 diabetes to Parkinson's disease aetiology Type 2 diabetes (T2D) and Parkinson's disease (PD) are chronic disorders that have a significant health impact on a global scale. Epidemiological, preclinical, and clinical research underpins the assumption that insulin resistance and chronic inflammation contribute to the overlapping aetiologies of T2D and PD. This narrative review summarises the recent evidence on the contribution of T2D to the initiation and progression of PD brain pathology. It also briefly discusses the rationale and potential of alternative pharmacological interventions for PD treatment. Parkinson’s disease advanced glycation end products diabetes hyperglycemia insulin resistance neuroinflammation reactive oxidative species ROS α-synuclein α-synuclein oligomers Parkinsonova bolezen napredni končni produkti glikacije sladkorna bolezen hiperglikemija odpornost proti inzulinu nevrovnetje reaktivne oksidativne vrste ROS α-sinuklein oligomeri α-sinukleina true false true Angleški jezik Slovenski jezik Članek v reviji 2024-11-18 15:28:01 2024-11-18 15:28:05 2024-11-22 14:56:47 0000-00-00 00:00:00 2024 0 0 44 str. iss. 8, art. 4358 Vol. 25 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-092 1422-0067 10.3390/ijms25084358 194916099 ijms-25-04358.pdf ijms-25-04358.pdf 1 2B2A4564FFB80CCC6DBFBB6C3697E50E 50cbd998b54a6daf0537bd762fe665cb03621aa59e66a852112f2079032aea23 24af77ff-a5b9-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=195812 https://www.mdpi.com/1422-0067/25/8/4358 1 f1eef38c-a5b8-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=195811 Medicinska fakulteta 0 0 0